BRAND NAMES
 MECHANISM OF ACTION
Triprolidine is a potent competitive histamine H1-receptor antagonist of the pyrrolidine class with mild central nervous system depressant properties which may cause drowsiness.
Triprolidine is indicated for the control of allergic manifestations associated with upper respiratory tract infections.
Preparations containing antihistamines have an atropine like action (anticholinergic properties). Therefore, they should be used with caution in patients with a history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease or hypertension.
- Triprolidine/ Alcohol/ CNS Depressants/ Tricyclic Antidepressants: Concurrent use may potentiate the CNS depressant effects of Triprolidine or of these agents.
- Triprolidine/ Monoamine Oxidase Inhibitors: Concurrent use may prolong and intensify the antimuscarinic effects and CNS depressant effects of Triprolidine.
- Triprolidine/ Ototoxic Medications: Symptoms of ototoxicity may be masked if Triprolidine is used concurrently with ototoxic drugs, particularly aminoglycoside antibiotics such as amikacin, dihydrostreptomycin, gentamicin, kanamycin, neomycin, streptomycin, tobramycin and viomycin.
 PREGNANCY AND LACTATION
 SIDE EFFECTS
Like many antihistamines, the most common side effect is drowsiness