Triprolidine

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Contents

[edit] BRAND NAMES

Triprolidine/pseudoephedrine: Actifed

[edit] STRUCTURE

Triprolidine.jpg

[edit] MECHANISM OF ACTION

Triprolidine is a potent competitive histamine H1-receptor antagonist of the pyrrolidine class with mild central nervous system depressant properties which may cause drowsiness.

[edit] INDICATIONS

Triprolidine is indicated for the control of allergic manifestations associated with upper respiratory tract infections.

[edit] PRECAUTIONS

Preparations containing antihistamines have an atropine like action (anticholinergic properties). Therefore, they should be used with caution in patients with a history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease or hypertension.

[edit] INTERACTIONS

  • Triprolidine/ Alcohol/ CNS Depressants/ Tricyclic Antidepressants: Concurrent use may potentiate the CNS depressant effects of Triprolidine or of these agents.
  • Triprolidine/ Monoamine Oxidase Inhibitors: Concurrent use may prolong and intensify the antimuscarinic effects and CNS depressant effects of Triprolidine.
  • Triprolidine/ Ototoxic Medications: Symptoms of ototoxicity may be masked if Triprolidine is used concurrently with ototoxic drugs, particularly aminoglycoside antibiotics such as amikacin, dihydrostreptomycin, gentamicin, kanamycin, neomycin, streptomycin, tobramycin and viomycin.

[edit] PREGNANCY AND LACTATION

Pregnancy Category C (US)

[edit] SIDE EFFECTS

Like many antihistamines, the most common side effect is drowsiness

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES