Travoprost

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Travoprost (Travatan) is one of a group of medicines called prostaglandin analogues. It works by reducing the pressure in the eye. It may be used on its own or with other drops e.g. beta-blockers, which also reduce pressure.

Travoprost eye drops are used to treat high pressure in the eye. This pressure can lead to an illness called glaucoma.

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[edit] BRAND NAMES

[edit] STRUCTURE

Travoprost.jpg

[edit] MECHANISM OF ACTION

Travoprost, is a prostaglandin F analogue. In the eye, prostaglandin increases the drainage of the watery fluid (aqueous humour) out of the eyeball. Travoprost acts in the same way and increases the outflow of aqueous humour via trabecular meshwork and uveoscleral pathways. This helps to reduce the intraocular pressure.

Raised pressure in the eye causes damage to the retina and to the optic nerve that sends signals from the eye to the brain. This can result in serious vision loss and even blindness. By lowering the pressure, Travoprost reduces the risk of damage.

Reduction of the intraocular pressure in man starts about 2 hours after administration and maximum effect is reached after 12 hours. Significant lowering of intraocular pressure can be maintained for periods exceeding 24 hours with a single dose.

[edit] INDICATIONS

Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

[edit] DOSAGE

The recommended dosage is one drop of Travoprost in the conjunctival sac of the affected eye(s) once daily.
Optimal effect is obtained if the dose is administered in the evening.

When using nasolacrimal occlusion or closing the eyelids gently, the systemic absorption is reduced. This may result in a decrease in systemic side effects and an increase in local activity

Remove contact lenses prior to application and wait 15 minutes after instillation of the dose before reinsertion

[edit] CONTRAINDICATIONS

  • Hypersensitivity to any component

[edit] WARNINGS AND PRECAUTIONS

  • Pigmentation: Travoprost may gradually change the eye colour by increasing the number of melanosomes (pigment granules) in melanocytes. This change may be permanent. Increased pigmentation of periorbital tissue (eyelid) and eyelashes has been reported as well.
  • Eyelash changes: Travoprost may increase the length, thickness, colour and/or number of eyelashes and may cause unusual hair growth on your eyelids. eyelash changes are usually reversible.

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US). Travoprost should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • It is unknown whether travoprost from eye drops is excreted in human breast milk. Animal studies have shown excretion of travoprost and metabolites in breast milk. The use of Travoprost by breastfeeding mothers is not recommended.

[edit] SIDE EFFECTS

Reported treatment-related undesirable effect include: conjunctival hyperemia (Usually mild), visual acuity, eye discomfort, foreign body sensation, pain and pruritus, iris hyperpigmentation, periocular hyperpigmentation, changes in eyelashes (increased length, thickness, number of lashes and discolouration), headache.

[edit] RELATED LINKS

Understanding Glaucoma

[edit] BIBLIOGRAPHY

[edit] REFERENCES