Tolnaftate

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Tolnaftate.jpg

[edit] MECHANISM OF ACTION

Tolnaftate is believed to inhibit the squalene epoxidase, an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal membrane). This results in deceased synthesis of ergosterol and accumulation of toxic squalene which, in turn, results in a defective cell membrane with altered permeability and leakage of cellular contents .

Tolnaftate is effective on dermatophytes (Epidermophyton , Trichophyton, Microsporum) but does not cover Candida albicans.

[edit] INDICATIONS

Topical treatment of tinea pedis (athlete's foot), tinea cruris, tinea corporis (ringworm), tinea barbae and tinea manum

Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm.

[edit] DOSAGE FORMS

Solution, powder, spray and cream

[edit] DOSAGE

  • Wash and dry the effected skin region.
  • Apply at least twice daily.


To get successful results during tinea pedis treatment, some measures are necessary:

  • Continue treatment with the cream for at least two weeks after the symptoms have cleared up to make sure the infection has been fully treated.
  • Appropriate shoes should be worn; shoes that facilitate air circulation and keep areas between fingers dry.
  • Socks should be changed at least once daily
  • Shoes should also be changed alternately.

[edit] CONTRAINDICATIONS

Hypersensitivity to tolnaftate

[edit] PRECAUTIONS

  • Unless otherwise recommended by physician, Tolnaftate should not be administered to children below 2 years of age.
  • It is only for external usage.

[edit] PREGNANCY AND LACTATION

Pregnant women and nursing mother: Tolnaftate is not advised to be used during pregnancy. Its usage is possible only with doctors careful evaluation based upon the assessment of benefits/risks ratio.

[edit] SIDE EFFECTS

Tolnaftate is a well tolerated drug. Skin irritation and allergic reactions are rare

[edit] RELATED LINKS

Athlete's Foot Treatments

http://www.tinactin.com/

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Antifungals
Ergosterol target : Cell membrane target Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors Imidazoles Topical: Bifonazole   Clotrimazole   Econazole   Fenticonazole   Ketoconazole   Isoconazole   Miconazole   Sertaconazole   Tioconazole
Triazoles Topical: Fluconazole   Terconazole
Systemic: Fluconazole   Itraconazole   Posaconazole   Voriconazole
Polyene antimycotics (ergosterol binding; they form pores in the membrane) Topical: Nystatin
Systemic: Amphotericin B
Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors Topical: Amorolfine   Naftifine   Terbinafine
Systemic: Terbinafine
Echinocandins (β-glucan synthase inhibitors) : Cell wall target Anidulafungin   Caspofungin   Micafungin
Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors Flucytosine
Mitotic inhibitors Griseofulvin
Others Ciclopirox