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Ticlopidine (Ticlid) is an antiplatelet drug. It is used to treat clotting of the blood.
Antiplatelet drugs work by reducing the ability of blood clotting cells (platelets) to stick to each other and to the walls of the blood vessels. This reduces the ability of blood to clot in unwanted places such as in narrowed blood vessels.
Ticlopidine is usually prescribed for one of two reasons:
- Patients at risk of having a stroke, who either cannot take aspirin or for whom aspirin was not effective.
- Patients who are about to receive, or who have recently received a coronary stent. A stent is a small metal tube that holds a blood vessel in the heart open. This is used to reduce chest tightness or pain (called angina), and also, heart attacks (called myocardial infarcts). Ticlopidine decreases the risk of a clot forming on the stent. Clots may cause a blockage of the blood vessel, leading to a heart attack.
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 MECHANISM OF ACTION
Ticlopidine, is an inhibitor of platelet aggregation. This means that it helps to prevent blood clots from forming. When the blood clots, this is due to special cells in the blood, the platelets, sticking together (aggregating).
Ticlopidine acts as an irreversible antagonist of the adenosine diphosphate (ADP) P2Y12 receptor. it binds to the platelet P2Y12 receptors and prevents ADP-mediated platelet activation of the glycoprotein GPIIb/IIIa complex. As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation.
Ticlopidine, by reducing the risk of a blood clot forming, it helps to prevent a second heart attack.