Terbinafine (Topical)

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[edit] BRAND NAMES

[edit] STRUCTURE

Terbinafine.jpg

[edit] MECHANISM OF ACTION

Terbinafine inhibits squalene epoxidase, this results in deceased synthesis of ergosterol and accumulation of toxic squalene (fungicidal effect). Ergosterol is an essential component of the fungal cell membrane. The inhibition of its synthesis results in accumulation of toxic 14α-methylated sterols and the production of a defective cell membrane with altered permeability and leakage of cellular contents.

[edit] INDICATIONS

Topical treatment of the following dermatologic infections:

  • Tinea (pityriasis) versicolor
  • Tinea pedis (athlete’s foot)
  • Tinea corporis (ringworm)
  • Tinea cruris (jock itch)

[edit] DOSAGE

Adults: Terbinafine (Topical) is applied once daily for all indications. Sufficient gel should be applied to cover the affected skin and surrounding area.

Duration and frequency of treatment

  • Interdigital type tinea pedis: Once a day for 1 week
  • Tinea corporis, tinea cruris: Once a day for 1 week
  • Pityriasis versicolor: Once a day for 1 week

Relief of clinicalvsymptoms usually occurs within a few days. Irregular use or premature discontinuation of treatment carries the risk of recurrence.

[edit] DOSAGE FORMS AND STRENGTHS

  • Terbinafine DermGel 0,1%

[edit] CONTRAINDICATIONS

  • Patients with a history of allergic reaction to terbinafine.

[edit] WARNINGS AND PRECAUTIONS

  • Avoid contact with the eyes, nose, mouth, or other mucous membranes.

[edit] INTERACTIONS

Potential interactions between Terbinafine (Topical), and other drugs have not been systematically evaluated.

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category B (US). Terbinafine (Topical) should be used only if clearly indicated during pregnancy.
  • Nursing Mothers: Because of the small amount of data on human neonatal exposure, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

[edit] SIDE EFFECTS

Local symptoms such as pruritus, skin exfoliation, application site pain, application site irritation, pigmentation disorder,skin burning sensation, erythema, scab, etc. may occur at the site of application. These harmless symptoms must be distinguished from hypersensitivity reactions including rash, which are reported in sporadic cases and require discontinuation of therapy. In case of accidental contact with the eyes terbinafine may be irritating to the eyes. In rare cases the underlying fungal infection may be aggravated.

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