Sertaconazole (Vaginal)

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Sertaconazole.jpg

[edit] MECHANISM OF ACTION

Sertaconazole is an antifungal agent of the imidazole class. It inhibits lanosterol 14α-demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol.

Ergosterol is an essential component of the fungal cell membrane. The inhibition of its synthesis results in accumulation of toxic 14α-methylated sterols and the production of a defective cell membrane with altered permeability and leakage of cellular contents.

[edit] INDICATIONS

Candidal vulvovaginitis (vaginal thrush)

[edit] DOSAGE

300 mg vaginal suppository: A single dose introduced deeply into the vagina, preferably while lying down, at night. The vaginal suppository can be used during menstruation. In general, 1 vaginal suppository suffices to eradicate the vaginal mycosis. However, if it persists, a second vaginal suppository can be applied alter 7 days..

[edit] CONTRAINDICATIONS

  • Patients who have a known or suspected sensitivity to sertaconazole
  • Pregnancy and lactation

[edit] PRECAUTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy and lactation: generally not recommended during pregnancy and lactation

[edit] SIDE EFFECTS

Rarely, slight local and transient erythematous reaction.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Antifungals
Ergosterol target : Cell membrane target Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors Imidazoles Topical: Bifonazole   Clotrimazole   Econazole   Fenticonazole   Ketoconazole   Isoconazole   Miconazole   Sertaconazole   Tioconazole
Triazoles Topical: Fluconazole   Terconazole
Systemic: Fluconazole   Itraconazole   Posaconazole   Voriconazole
Polyene antimycotics (ergosterol binding; they form pores in the membrane) Topical: Nystatin
Systemic: Amphotericin B
Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors Topical: Amorolfine   Naftifine   Terbinafine
Systemic: Terbinafine
Echinocandins (β-glucan synthase inhibitors) : Cell wall target Anidulafungin   Caspofungin   Micafungin
Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors Flucytosine
Mitotic inhibitors Griseofulvin
Others Ciclopirox