Sertaconazole (Topical)

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[edit] BRAND NAMES

[edit] STRUCTURE

Sertaconazole.jpg

[edit] MECHANISM OF ACTION

Sertaconazole is an antifungal agent of the imidazole class. It inhibits lanosterol 14α-demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol.

Ergosterol is an essential component of the fungal cell membrane. The inhibition of its synthesis results in accumulation of toxic 14α-methylated sterols and the production of a defective cell membrane with altered permeability and leakage of cellular contents.

[edit] INDICATIONS

Treatment of superficial skin mycoses such as dermatophytosis (including tinea corporis, tinea cruris, tinea manus, tinea barbae and tinea pedis), cutaneous candidiasis, pityriasis versicolor and seborrhoeic dermatitis of the scalp, and in the U.S. for tinea pedis only

[edit] DOSAGE

  • Adults: 2% cream applied to affected area once or twice daily for 2-4 weeks.

[edit] CONTRAINDICATIONS

  • Patients who have a known or suspected sensitivity to sertaconazole

[edit] PRECAUTIONS

If irritation or sensitivity develops with the use of Topical Sertaconazole , treatment should be discontinued and appropriate therapy instituted.

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US). Topical Sertaconazole should be used during pregnancy only if clearly needed.
  • Nursing Mothers: caution should be exercised when prescribing ERTACZO® Cream, 2%, to a nursing woman.

[edit] SIDE EFFECTS

The following cutaneous adverse events were reported: contact dermatitis, erythema, pruritus, vesiculation, desquamation, and hyperpigmentation.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Antifungals
Ergosterol target : Cell membrane target Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors Imidazoles Topical: Bifonazole   Clotrimazole   Econazole   Fenticonazole   Ketoconazole   Isoconazole   Miconazole   Sertaconazole   Tioconazole
Triazoles Topical: Fluconazole   Terconazole
Systemic: Fluconazole   Itraconazole   Posaconazole   Voriconazole
Polyene antimycotics (ergosterol binding; they form pores in the membrane) Topical: Nystatin
Systemic: Amphotericin B
Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors Topical: Amorolfine   Naftifine   Terbinafine
Systemic: Terbinafine
Echinocandins (β-glucan synthase inhibitors) : Cell wall target Anidulafungin   Caspofungin   Micafungin
Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors Flucytosine
Mitotic inhibitors Griseofulvin
Others Ciclopirox