BRAND NAMES
- International: Onsior
 MECHANISM OF ACTION
Robenacoxib is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class. It is a potent and selective inhibitor of the cyclooxygenase 2 enzyme (COX-2).
Two forms of cyclooxygenase have been described in mammals:
- The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function.
- The inducible cyclooxygenase, COX-2, is responsible for the production of mediators including PGE2 which induce pain, inflammation or fever..
Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 reduces pain and inflammation associated with musculoskeletal disorders.
- Cats: Robenacoxib is indicated for the control of postoperative pain and inlammation associated with orthopedic surgery, ovariohysterectomy, and castration, in cats ≥ 5.5 lbs (2.5 kg) and ≥ 6 months of age; for up to a maximum of 3 days
- Dogs: Robenacoxib is indicated for the control of pain and inflammation associated with chronic osteoarthritis or orthopaedic or soft tissue surgery in dogs
Robenacoxib tablets: Robenacoxib tablets should be given on an empty stomach or with only a small amount of food
Cats: The first dose should be administered approximately 30 minutes prior to surgery, at the same time as the pre-anesthetic agents are given.
5.5 to 13.2 lbs (2.5 to 6 kg): 1 whole 6 mg tablet once daily
13.3 to 26.4 lbs (6.1 to 12 kg): 2 whole 6 mg tablets once daily
Dogs: Administer orally once per day at a dosage of 1 mg/kg bodyweight with a range of 1-2 mg/kg.
| Bodyweight (kg)
|| Number of tablets by size|
||5 mg||10 mg||20 mg||40 mg|
| 2.5 – <5
| 5 – <10
| 10 – <20
||1 tablet|| |
| 20 – <40
| 40 – 80
- Animals suffering from gastrointestinal ulceration.
- Concomitant use with other anti-inflammatory drugs, such as other NSAIDs or corticosteroids
- Known hypersensitivity to robenacoxib.
- For cats use Robenacoxib 6 mg Tablets for Cats
- Use in cats or dogs with impaired cardiac, renal or hepatic function or in cats that are dehydrated, hypovolaemic or hypotensive may involve additional risks. If use cannot be avoided, these cats require careful monitoring.
- Robenacoxib must not be administered in conjunction with other NSAIDs. Pre-treatment with other anti-inflammatory medicines may result in additional or increased adverse effects and, accordingly, a treatment-free period with such substances should be observed for at least 24 hours before the commencement of treatment with Robenacoxib. The treatment-free period, however, should take into account the pharmacokinetic properties of the products used previously.
 SIDE EFFECTS
Mild and transient diarrhea, soft stool or vomiting were commonly reported. In very rare cases, lethargy may be observed.
 RELATED LINKS
|Non-steroidal anti-inflammatory drugs (NSAIDs)|
|Non-selective (COX-1 and COX-2 inhibitors)||Aceclofenac • Acetylsalicylic acid • Benzydamine • Diclofenac • Flurbiprofen • Ibuprofen • Indometacin • Ketoprofen • Ketorolac • Ketorolac • Lornoxicam • Mefenamic acid • Morniflumate • Nabumetone • Naproxen • Niflumic acid • Piroxicam • Tenoxicam|
|Relatively COX-2 selective||Meloxicam • Nimesulide|
|COX-2 selective inhibitors (Coxibs)||Celecoxib • Etoricoxib • Parecoxib|
|Ophthalmic NSAIDs||Bromfenac (ophthalmic) • Diclofenac (ophthalmic) • Flurbiprofen (ophthalmic) • Ketorolac (ophthalmic) • Nepafenac (ophthalmic)|
|Veterinary use||Carprofen • Deracoxib • Firocoxib • Mavacoxib • Robenacoxib|