Oxatomide (Oral route)

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Oxatomide.jpg

[edit] MECHANISM OF ACTION

Oxatomide exerts antihistamine (H1) effects thus preventing the effects of histamine released as a result of allergen-antibody interactions, and this leads to a decrease in the symptoms of allergy.

[edit] INDICATIONS

Symptomatic treatment of allergic rhinitis and chronic urticaria.

Oxatomide relieves the classical nasal and ocular symptoms associated with hay-fever.

In cases of chronic urticaria Oxatomide reduces the severity of the erythema, and pruritis.

[edit] DOSAGE

ADULTS: 30 mg morning and evening.

CHILDREN: 1 mg/kg body mass twice daily.

[edit] CONTRAINDICATIONS

The safety of Oxatomide in pregnant or lactating women has not been established. Oxatomide should not be administered to pregnant or lactating women.

[edit] WARNINGS AND PRECAUTIONS

Oxatomide may lead to drowsiness and impaired concentration, which may be aggravated by simultaneous intake of alcohol or other central nervous system depressant agents.

Patients should be warned against taking charge of vehicles or machinery or performing potentially hazardous tasks where loss of concentration may lead to accidents.

In infants and children, Oxatomide may act as a cerebral stimulant and symptoms of overdosage may include convulsions and hyperpyrexia.

[edit] INTERACTIONS

Patients are warned that Oxatomide may enhance the sedative effect of central nervous system depressants including alcohol, barbiturates, hypnotics, narcotic analgesics, sedatives and tranquillisers.

[edit] PREGNANCY AND LACTATION

The safety of Oxatomide in pregnant or lactating women has not been established. Oxatomide should not be administered to pregnant or lactating women.

[edit] SIDE EFFECTS

Sedation, varying from slight drowsiness to deep sleep and including inability to concentrate, lassitude, dizziness, hypotension, muscular weakness, and inco-ordination. Other side-effects include gastrointestinal disturbances such as nausea, vomiting, diarrhoea or constipation, and epigastric pain. Oxatomide may produce headache, blurred vision, tinnitus, elation or depression, irritability, nightmares, anorexia, difficulty in micturition, dryness of the mouth, tightness of the chest and tingling, heaviness and weakness of the hands.

Dyskinetic neurological reactions have been observed.

Administration of Oxatomide may cause allergy. Local application of antihistamines carries a risk of skin sensitization with eczematous eruptions, but dermatological reactions may also result from oral administration. Blood disorders, including agranulocytosis and haemolytic anaemia have been reported.

Since Oxatomide has anticholinergic properties, it should be used with care in conditions liable to be exacerbated or otherwise adversely affected by atropine, such as glaucoma and prostatic hypertrophy. The side-effect of anticholinergic drugs such as atropine and tricyclic antidepressants may be enhanced by the concomitant administration of Oxatomide. Oxatomide may mask warning symptoms of damage caused by ototoxic drugs such as the amino-glycoside antibiotics. Oxatomide may affect the metabolism of drugs in the liver.

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