Olopatadine (Eye drops)
 BRAND NAMES
 MECHANISM OF ACTION
Olopatadine is a potent selective antiallergic/antihistaminic agent that exerts its effects through multiple distinct mechanisms of action:
- It antagonises histamine (the primary mediator of allergic response in humans) and prevents histamine induced inflammatory cytokine production by human conjunctival epithelial cells.
- Olopatadine also acts as an inhibitor of the release of pro-inflammatory mediators from the mast cell
Treatment of ocular signs and symptoms of seasonal allergic conjunctivitis
The dose is one drop in the conjunctival sac of the affected eye(s) twice daily (8 hourly). Treatment may be maintained for up to four months, if considered necessary.
Olopatadine (Eye drops) may be used in paediatric patients three years of age and older at the same dose as in adults.
Hypersensitivity to Olopatadine or to any of the excipients
 WARNINGS AND PRECAUTIONS
Although administered topically, Olopatadine (Eye drops) is absorbed systemically. If signs of serious reactions or hypersensitivity occur, discontinue the use of this treatment.
olopatadine (Eye drops) is unlikely to result in metabolic interactions with other concomitantly administered active substances.
 PREGNANCY AND LACTATION
- Pregnancy Category C (US). Olopatadine (Eye drops) should be used in pregnant women only if the potential benefit to the mother justifies the potential risk to the embryo or fetus.
- Available data in animals have shown excretion of olopatadine in milk following oral administration. Olopatadine (Eye drops) should not be used during breast-feeding
 SIDE EFFECTS
Common adverse reactions (≥1/100 to <1/10):
- eye pain, eye irritation, dry eye, abnormal sensation in eyes
- nasal dryness
 RELATED LINKS
|For systemic use||Bilastine • Cetirizine • Chlorphenamine • Cyproheptadine • Dexchlorpheniramine • Desloratadine • Dimetindene (Oral route) • Ebastine • Fexofenadine • Ketotifen (Oral route) • Levocetirizine • Loratadine • Mequitazine • Mizolastine • Oxatomide (Oral route) • Rupatadine|
|For topical use||Dexchlorpheniramine (Topical) • Diphenhydramine • Dimetindene (Topical) • Oxatomide (Topical) • Promethazine|
|Nasal spray||Azelastine (Nasal spray) • Levocabastine (Nasal spray)|
|Eye drops||Azelastine (Eye drops) • Epinastine • Ketotifen (Eye drops) • Levocabastine (Eye drops) • Olopatadine (Eye drops)|
|Combinations||Cetirizine/Pseudoephedrine • Desloratadine/Pseudoephedrine|