Nordazepam

From Drugs Prescribing Information
Jump to: navigation, search

Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Nordazepam.jpg

[edit] MECHANISM OF ACTION

Nordazepam, like other Benzodiazepines bind to specific sites on the gamma-aminobutyric acid-A (GABAA) receptors. This enhances the effects of GABA by increasing its affinity for the GABAA receptor.

Activation of the GABAA receptor, which is linked to a chloride channel (Cl-), results in an influx of Cl- into the neurone causing hyperpolarisation, which results in inhibitory effects on the central nervous system.

Benzodiazepines action on GABAA receptors appears to produce their anxiolytic, sedative, muscle relaxant, hypnotic and anticonvulsant actions.

Nordazepam is one of the major metabolites of Diazepam. It is classified as a long-acting benzodiazepine. Its half-life in human plasma reported to be in the range of 26 to 86 hours and peak concentrations in plasma occur approximately 1-3 hours following administration.

[edit] INDICATIONS

  • Symptomatic relief of tension, anxiety and agitation. Note that anxiety or tension associated with the normal stress of everyday life usually does not require treatment with benzodizepines
  • Short-term treatment of insomnia

[edit] DOSAGE

Insomnia: The recommended dose for most adults is 10 mg before retiring

Treatment should begin with low doses, gradually increasing to the optimum level. The duration of treatment should be as short as possible

[edit] CONTRAINDICATIONS

  • Hypersensitivity to Nordazepam or to any drug in the benzodiazepine class
  • Severe liver failure
  • Pregnancy and lactation
  • Myasthenia gravis (Nordazepam could increase the muscle weakness)
  • Severe respiratory failure or sleep apnea syndrome

[edit] PRECAUTIONS

  • Do not drive or do other dangerous activities after taking Nordazepam until you feel fully awake.
  • Do not drink alcohol
  • Caution is required in patients with chronic respiratory failure (risk of respiratory depression).
  • Use of benzodiazepines can lead to dependence. This risk increases with dose and duration of treatment.

[edit] INTERACTIONS

Benzodiazepines, including Nordazepam, produce additive CNS depressant effects when co-administered with other medications which themselves produce CNS depression (e.g. barbiturates, alcohol, sedatives, tricyclic antidepressants, antipsychotics, skeletal muscle relaxants, antihistamines or narcotic analgesics and anaesthetics).

[edit] PREGNANCY AND LACTATION

  • Contraindicated during the first trimester of pregnancy and not recommended for the rest of the pregnancy and in nursing mothers

[edit] SIDE EFFECTS

The most common possible side effects are: Drowsiness, headache, tiredness, nervousness, dizziness, uncoordinated movements and “hangover” feeling the day after.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

http://www.dottnet.it/TFI/Allegati.aspx?file=2011-12-004007-Madar%20Notte.pdf

[edit] REFERENCES

Sedatives / Hypnotics / Anxiolytics
Benzodiazepines Benzodiazepines (Anxiolytics)‎ Alprazolam (Xanax)   Bromazepam (Lexotan, Lexotanil)   Chlordiazepoxide (Librium)   Clobazam (Frisium)   Clorazepate (Tranxene)   Clotiazepam (Rizen, Tienor)   Delorazepam (EN)   Diazepam (Valium)   Etizolam (Depas)   Ketazolam   Lorazepam (Ativan, Control, Lorans, Tavor, Temesta)   Lormetazepam (Noctamid)   Nordazepam (Nordaz)   Oxazepam (Serepax)   Prazepam (Demetrin, Lysanxia)
Benzodiazepines (Hypnotics) Brotizolam (Lendormin, Bondormin, Dormex, Sintonal, Noctilan)   Clobazam (Frisium)   Estazolam (Esilgan, ProSom)   Etizolam (Depas, Pasaden, Etilaam, Etizest)   Flunitrazepam (Rohypnol)   Flurazepam (Dalmadorm, Dalmane, Felison, Flunox, Valdorm)   Ketazolam (Anseren, Anxon)   Lorazepam (Ativan, Control, Lorans, Tavor, Temesta)   Lormetazepam (Loramet, Minias, Noctamid, Pronoctan, Evamyl)   Midazolam (Dormicum, Hypnovel)   Nitrazepam (Mogadon, Nitrados, Numbon, Radedorm, Alodorm)   Nordazepam (Madar, Nordaz, Stilny, Tranxilium N)   Temazepam (Normison, Restoril, Tenox, Temaze)   Triazolam (Halcion, Hypam, Rilamir)
Non-Benzodiazepine Hypnotics Eszopiclone (Lunesta)   Zolpidem (Ambien, Stilnox, Hypnogen, Sanval, Stilnoct, Zoldem, Zolsana)   Zopiclone (Imovane, Zimovane)
Melatonin agonists Melatonin (Circadin)   Ramelteon (Rozerem)
Orexin agonists Suvorexant (Belsomra)