Mometasone (Nasal spray)

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[edit] BRAND NAMES

[edit] STRUCTURE

Mometasone.jpg

[edit] MECHANISM OF ACTION

Mometasone is a synthetic corticosteroid, exhibiting anti-inflammatory, anti-pruritic and vasoconstrictive properties.

Corticosteroids have a wide range of inhibitory activities against multiple cell types (e.g. mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators(e.g. histamine, eicosanoids, leukotrienes, and cytokines) involved in allergic mediated inflammation.

[edit] INDICATIONS

  • Relief of the symptoms of seasonal or perennial allergic and nonallergic (vasomotor) rhinitis
  • Prophylaxis of Seasonal Allergic Rhinitis
  • Treatment of nasal polyps

[edit] DOSAGE

Shake the suspension spray bottle well before using it.

  • Treatment of seasonal or perennial allergic and nonallergic (vasomotor) rhinitis:
    • Adults and children 12 years of age and older: The usual dose is 100 mcg (2 sprays) into each nostril, once daily
    • Children 2-11 years of age: 50 mcg (1 spray) in each nostril, once daily. (FDA approved)
  • Prophylaxis of Seasonal Allergic Rhinitis
    • Adults and Adolescents 12 Years of Age and Older: The recommended dose is 100 mcg (2 sprays) in each nostril once daily. In patients with a known seasonal allergen that precipitates nasal symptoms of seasonal allergic rhinitis, prophylaxis is recommended 2 to 4 weeks prior to the anticipated start of the pollen season.
  • Nasal Polyps in patients 18 years of age and older: 100 mcg (2 sprays) into each nostril once daily. If symptoms are not controlled the doctor may increase the dose to 100 mcg (2 sprays) into each nostril twice daily.

[edit] CONTRAINDICATIONS

Hypersensitivity to any of the ingredients of the preparation

[edit] WARNINGS AND PRECAUTIONS

  • Mometasone Nasal spray has an inhibitory effect on nasal wound healing. Do not use it until healing has occurred.
  • Development of localized infections of the nose and pharynx with Candida albicans may occur
  • Nasal septum perforation have been reported following the intranasal application of corticosteroids. As with any long-term topical treatment of the nasal cavity, patients using Mometasone Nasal spray over several months or longer should be examined periodically for possible changes in the nasal mucosa.
  • Intranasal corticosteroids may cause a reduction in growth velocity when administered to pediatric patients. Therefore, children should be maintained on the lowest possible efficacious dose which delivers adequate symptom control and growth of children receiving prolonged treatment should be regularly monitored.

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US). Mometasone Nasal Spray should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Nursing Mothers: It is not known if mometasone is excreted in human milk. Because other corticosteroids are excreted in human milk, caution should be exercised if administered to a nursing woman.

[edit] SIDE EFFECTS

Upper respiratory tract infection, irritation of the nose, unpleasant taste and smell, headache and epistaxis.

Hypersensitivity reactions including skin rash and edema of the face or tongue may occur.

  • Rarely: Anaphylactic reactions and bronchospasm.
  • Very rarely: Glaucoma, raised intraocular pressure and cataract.
  • Extremely rarely: nasal ulceration and nasal septal perforation.

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