Mometasone (Inhaler)

From Drugs Prescribing Information
Jump to: navigation, search
Click on "►" to expand:

Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Mometasone.jpg

[edit] MECHANISM OF ACTION

Airway inflammation is an important component in the pathogenesis of asthma. Mometasone furoate is an inhaled glucocorticoid, it works in the air passages of the lungs by reducing inflammation and keeping the airways open, making it easier to breathe. Glucocorticoids have multiple antiinflammatory effects, inhibiting both inflammatory cells and release of inflammatory mediators.

[edit] INDICATIONS

To PREVENT shortness of breath or asthma. It won't give a fast relief once an acute bronchospasm attack has started

[edit] DOSAGE

Mometasone must be inhaled rapidly and deeply and mouth must be rinsed after inhalation

  • Adults: 200-400 mcg once daily in the evening, Maximum 800 mcg (400 mcg twice daily)
  • Children 4-11 years of age: 100 mcg once daily in the evening

[edit] CONTRAINDICATIONS

  • Acute bronchospasm attack requiring intensive measures

[edit] WARNINGS AND PRECAUTIONS

  • Candida albicans infection of the mouth and pharynx. Monitor patients periodically for signs of adverse effects in the mouth and pharynx. Advise patients to rinse mouth after inhalation
  • Mometasone (Inhaler) should not be used for relief of acute bronchospasm attacks
  • Hypersensitivity reactions including anaphylaxis, angioedema, pruritus, and rash have been reported. Discontinue Mometasone (Inhaler) if such reactions occur.
  • Potential worsening of existing tuberculosis; fungal, bacterial, viral, or parasitic infection; or ocular herpes simplex. More serious or even fatal course of chickenpox or measles in susceptible patients. Use caution in patients with the above because of the potential for worsening of these infections
  • Decreases in bone mineral density (BMD) have been observed with long-term administration of products containing inhaled corticosteroids
  • Glaucoma, increased intraocular pressure, and cataracts have been reported following the long-term administration of inhaled corticosteroids.
  • Orally inhaled corticosteroids may cause a reduction in growth velocity when administered to pediatric patients. Monitor the growth of pediatric patients
  • Paradoxical bronchospasm may occur with Mometasone (Inhaler). Treat bronchospasm immediately with a fast-acting inhaled bronchodilator (Salbutamol) and discontinue use of Mometasone (Inhaler).

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US). It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • It is not known if mometasone furoate is excreted in human milk. Caution should be exercised when Mometasone inhaler is administered to a nursing woman.

[edit] SIDE EFFECTS

May cause candida albicans infection of the mouth and pharynx (rinsing your mouth and gargling with water after using the inhaler may avoid such inconvenience), headache, allergic rhinitis, pharyngitis, upper respiratory tract infection, dyspepsia, dysmenorrhea, musculoskeletal pain and back pain.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

Asmanex prescribing information

[edit] REFERENCES

Asthma / Chronic obstructive pulmonary disease (COPD)
Adrenergics, inhalants Short acting β2-agonists Fenoterol (Berotec)   Levosalbutamol (Xopenex)   Salbutamol (Ventolin)   Terbutaline (Bricanyl)
Long acting β2-agonists (LABA) Arformoterol (Brovana)   Clenbuterol (Spiropent)   Formoterol (Foradil)   Salmeterol (Serevent)
Ultra long acting β2-agonists Indacaterol   Olodaterol   Vilanterol
Inhaled corticosteroids Beclomethasone (Inhaler)   Budesonide (Inhaler)   Ciclesonide (Inhaler)   Flunisolide (Inhalation suspension)   Fluticasone (Inhaler)   Mometasone (Inhaler)
Anticholinergics (Muscarinic antagonists) Aclidinium bromide   Glycopyrronium bromide   Ipratropium bromide   Oxitropium bromide (Inhalation suspension)   Tiotropium bromide
Mast cell stabilizers Cromoglicate   Nedocromil
Monoclonal anti-IgE antibody Omalizumab
Xanthine derivatives Aminophylline   Bamifylline   Doxofylline   Dyphylline   Theophylline
Eicosanoid inhibition Leukotriene antagonists Montelukast   Pranlukast   Zafirlukast
Thromboxane receptor antagonists Ramatroban   Seratrodast
Non-xanthine PDE4 inhibitors Ibudilast   Roflumilast
Combination products Corticosteroid + Long acting Beta2 agonist Beclomethasone/Formoterol (Inhaler)   Fluticasone/Salmeterol (Inhaler)   Fluticasone/Vilanterol   Mometasone/Formoterol
Corticosteroid + Short acting Beta2 agonist Beclomethasone/Salbutamol   Salbutamol/Flunisolide (Inhalation suspension)   Salbutamol/Flunisolide (Inhaler)
Short acting Beta2 agonist + Muscarinic antagonist Fenoterol/Ipratropium bromide (Inhaler)   Levosalbutamol/Ipratropium   Salbutamol/Ipratropium bromide