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Lormetazepam, like other Benzodiazepines bind to specific sites on the gamma-aminobutyric acid-A (GABAA) receptors. This enhances the effects of GABA by increasing its affinity for the GABAA receptor.

Activation of the GABAA receptor, which is linked to a chloride channel (Cl-), results in an influx of Cl- into the neurone causing hyperpolarisation, which results in inhibitory effects on the central nervous system.

Benzodiazepines action on GABAA receptors appears to produce their anxiolytic, sedative, muscle relaxant, hypnotic and anticonvulsant actions.

Lormetazepam is a short-intermediate-acting benzodiazepine, its half-life in human plasma reported to be in the range of 10 to 12 hours


Short term treatment of insomnia when it is disabling or subjecting the individual to extreme distress.

[edit] DOSAGE

  • Adults: The recommended dose is 0.5 to 1.5 mg before retiring
  • Elderly: The lower adult dose is preferable for elderly patients

Treatment should begin with low doses, gradually increasing to the optimum level. The duration of treatment should be as short as possible (Generally, it varies from a few days to 2 weeks, with a maximum of 4 weeks including the tapering off process)


  • Hypersensitivity to Lormetazepam or to any drug in the benzodiazepine class
  • Severe liver failure
  • Pregnancy (especially during the first and last trimesters) and during lactation
  • Myasthenia gravis (Lormetazepam could increase the muscle weakness)
  • Severe respiratory failure
  • Sleep apnoea syndrome (a condition where you stop breathing whilst asleep)


  • Do not drive or do other dangerous activities after taking Lormetazepam until you feel fully awake.
  • Do not drink alcohol
  • Caution is required in patients with chronic respiratory failure (risk of respiratory depression).
  • Use of benzodiazepines can lead to dependence. This risk increases with dose and duration of treatment.
  • Lormetazepam should not be used alone in depressed patients with associated insomnia since it may induce suicide or aggressive behaviour.


Benzodiazepines, including Lormetazepam, produce additive CNS depressant effects when co-administered with other medications which themselves produce CNS depression (e.g. barbiturates, alcohol, sedatives, tricyclic antidepressants, antipsychotics, skeletal muscle relaxants, antihistamines or narcotic analgesics and anaesthetics).


  • Not reccomended during pregnancy (especially during the first and last trimesters)
  • Not recommended in nursing mothers


Possible side effects include: Daytime drowsiness, reduced alertness, confusion, depression, memory impairment, headache, muscle weakness and poor muscle control.

Rare unwanted effects include: liver function changes and low blood pressure.





Sedatives / Hypnotics / Anxiolytics
Benzodiazepines Benzodiazepines (Anxiolytics)‎ Alprazolam (Xanax)   Bromazepam (Lexotan, Lexotanil)   Chlordiazepoxide (Librium)   Clobazam (Frisium)   Clorazepate (Tranxene)   Clotiazepam (Rizen, Tienor)   Delorazepam (EN)   Diazepam (Valium)   Etizolam (Depas)   Ketazolam   Lorazepam (Ativan, Control, Lorans, Tavor, Temesta)   Lormetazepam (Noctamid)   Nordazepam (Nordaz)   Oxazepam (Serepax)   Prazepam (Demetrin, Lysanxia)
Benzodiazepines (Hypnotics) Brotizolam (Lendormin, Bondormin, Dormex, Sintonal, Noctilan)   Clobazam (Frisium)   Estazolam (Esilgan, ProSom)   Etizolam (Depas, Pasaden, Etilaam, Etizest)   Flunitrazepam (Rohypnol)   Flurazepam (Dalmadorm, Dalmane, Felison, Flunox, Valdorm)   Ketazolam (Anseren, Anxon)   Lorazepam (Ativan, Control, Lorans, Tavor, Temesta)   Lormetazepam (Loramet, Minias, Noctamid, Pronoctan, Evamyl)   Midazolam (Dormicum, Hypnovel)   Nitrazepam (Mogadon, Nitrados, Numbon, Radedorm, Alodorm)   Nordazepam (Madar, Nordaz, Stilny, Tranxilium N)   Temazepam (Normison, Restoril, Tenox, Temaze)   Triazolam (Halcion, Hypam, Rilamir)
Non-Benzodiazepine Hypnotics Eszopiclone (Lunesta)   Zolpidem (Ambien, Stilnox, Hypnogen, Sanval, Stilnoct, Zoldem, Zolsana)   Zopiclone (Imovane, Zimovane)
Melatonin agonists Melatonin (Circadin)   Ramelteon (Rozerem)
Orexin agonists Suvorexant (Belsomra)