Levomepromazine

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Levomepromazine.jpg

[edit] MECHANISM OF ACTION

Levomepromazine is an aliphatic phenothiazine neuroleptic drug (typical antipsychotic). Levomepromazine resembles other phenothiazines with aliphatic side chain: promazine (Talofen) and chlorpromazine (Thorazine) in the pattern of its pharmacology. It has high anti-H1, anti-alpha1 and anticholinergic effects, but acts little on the dopaminergic system and therefore is considered a low-potency antipsychotic.

[edit] INDICATIONS

  • Psychotic disturbances: Acute and chronic schizophrenias, Senile psychoses and Manic depressive syndromes
  • Management of terminal pain and accompanying anxiety and distress
  • Treatment of nausea and vomiting of central origin

[edit] DOSAGE

[edit] CONTRAINDICATIONS

[edit] WARNINGS AND PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

  • Sedation and drowsiness
  • Extrapyramidal effects
  • Dryness of mucous membranes , Urinary retention.
  • Orthostatic hypotension especially in elderly patients.
  • Tachycardia
  • Agranulocytosis (rare)
  • Weight gain
  • Photosensitivity and allergic skin reactions have occasionally been reported.
  • Increase LFT (liver function tests). Routine tests are advisable during prolonged therapy.
  • Rare cases of cholestatic jaundice without liver damage
  • Elevated prolactin levels: breast enlargement, galactorrhea, impotence in men and irregular menstrual cycles or absence of menstruation in women
  • Necrotizing enterocolitis, which can be fatal, has been very rarely reported in patients treated with Levomepromazine

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES