BRAND NAMES
 MECHANISM OF ACTION
Levomepromazine is an aliphatic phenothiazine neuroleptic drug (typical antipsychotic). Levomepromazine resembles other phenothiazines with aliphatic side chain: promazine (Talofen) and chlorpromazine (Thorazine) in the pattern of its pharmacology. It has high anti-H1, anti-alpha1 and anticholinergic effects, but acts little on the dopaminergic system and therefore is considered a low-potency antipsychotic.
- Psychotic disturbances: Acute and chronic schizophrenias, Senile psychoses and Manic depressive syndromes
- Management of terminal pain and accompanying anxiety and distress
- Treatment of nausea and vomiting of central origin
 WARNINGS AND PRECAUTIONS
 PREGNANCY AND LACTATION
 SIDE EFFECTS
- Sedation and drowsiness
- Extrapyramidal effects
- Dryness of mucous membranes , Urinary retention.
- Orthostatic hypotension especially in elderly patients.
- Agranulocytosis (rare)
- Weight gain
- Photosensitivity and allergic skin reactions have occasionally been reported.
- Increase LFT (liver function tests). Routine tests are advisable during prolonged therapy.
- Rare cases of cholestatic jaundice without liver damage
- Elevated prolactin levels: breast enlargement, galactorrhea, impotence in men and irregular menstrual cycles or absence of menstruation in women
- Necrotizing enterocolitis, which can be fatal, has been very rarely reported in patients treated with Levomepromazine
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