Levocetirizine

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Levocetirizine is a non-sedating antihistamine. It is used to treat symptoms associated with allergic conditions, such as: Allergic rhinitis (hay fever) and urticaria (itchy rash similar to nettle rash)

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[edit] BRAND NAMES

[edit] STRUCTURE

Levocetirizine.jpg

[edit] MECHANISM OF ACTION

Levocetirizine, the active enantiomer of cetirizine, is a third-generation non-sedative antihistamine; its principal effects are mediated via selective inhibition of H1 receptors resulting in suppression of histaminic edema, flare, and pruritus.

Levocetirizine does not appear to cross the blood-brain barrier (BBB); therefore, appears to have a low potential for sedation in usual doses

[edit] INDICATIONS

  • Symptomatic treatment of Urticaria
  • Seasonal and perennial allergic rhinitis to relief symptoms such as sneezing, rhinorrhea and nasal pruritus, occular pruritus and tearing.

[edit] DOSAGE

  • Adults and children 12 years and older: : 5 mg once daily in the evening
  • Children 6 to 11 Years: : 2.5 mg once daily in the evening
  • Children 6 months to 5 Years: : 1.25 mg once daily in the evening

[edit] CONTRAINDICATIONS

  • Hypersensitivity to Levocetirizine or to Cetirizine
  • Severe renal impairment (Creatinine Clearance <10 ml/min)

[edit] WARNINGS AND PRECAUTIONS

  • Somnolence has been reported in patients taking Levoetirizine. Caution should be exercised when driving a car or operating potentially dangerous machinery.
  • Avoid concurrent use of alcohol or other central nervous system depressants
  • Urinary retention has been reported post-marketing. Levocetirizine should be used with caution in patients with predisposing factors of urinary retention (e.g. spinal cord lesion, prostatic hyperplasia) as it may increase the risk, and should discontinue it if urinary retention occurs.

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category B (US). Levocetirizine should be used during pregnancy only if clearly needed.
  • Nursing mothers: Cetirizine has been reported to be excreted in human breast milk. Because levocetirizine is also expected to be excreted in human milk, its use in nursing mothers is not recommended.

[edit] SIDE EFFECTS

Generally Levocetirizine is well tolerated. However, a few side effects like headache, dizziness, nausea, dry mouth, fatigue, weakness, somnolence, rash have been reported rarely

[edit] RELATED LINKS

Xyzal mechanism

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