BRAND NAMES
 MECHANISM OF ACTION
Ketorolac is a potent nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic activities. Ketorolac inhibits the enzyme, cyclooxygenase (both COX-1 and COX-2 isoenzymes), an early component of the arachidonic acid cascade, resulting in the reduced formation of prostaglandins. Prostaglandins act as messenger molecules in the process of inflammation and are involved in the way we feel pain and the development of fever.
- Short-term (≤5 days) management of moderately severe, acute pain following surgical procedures, that requires analgesia at the opioid level
- Hypersensitivity to Ketorolac or to any other NSAID
- As prophylactic analgesic before any major surgery
- Patients with severe heart failure.
- Patients with severe renal failure (glomerular filtration below 30 mL/min).
- Patients with conditions involving an increased tendency to bleeding
- Active gastrointestinal bleeding or perforation
- In labor and delivery because, through its prostaglandin synthesis inhibitory effect, it may adversely affect fetal circulation and inhibit uterine musculature, thus increasing the risk of uterine hemorrhage.
- Nursing mothers
 PREGNANCY AND LACTATION
 SIDE EFFECTS
 RELATED LINKS