Gabapentin

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Gabapentin.jpg

[edit] MECHANISM OF ACTION

Gabapentin is an anticonvulsant drug that has analgesic properties. It is structurally related to the neurotransmitter GABA and selectively interacts with the α2δ subunit of voltage dependent calcium channels, producing a reduction in Ca2+ channel influx at the nerve terminals and, consequently, a reduction in the release of several excitatory neurotransmitters including glutamate, norepinephrine and substance P

[edit] INDICATIONS

  • Gabapentin is indicated for the management of neuropathic pain in adults (Diabetic neuropathy and post-herpetic neuralgia)
  • Gabapentin helps to minimize fibromyalgia pain [1]
  • Gabapentin improves sensory and motor symptoms in restless legs syndrome [2]
  • Gabapentin is also indicated as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.
  • Gabapentin is also indicated as adjunctive therapy in the treatment of partial seizures in pediatric patients age 3–12 years.

[edit] DOSAGE

[edit] CONTRAINDICATIONS

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

[edit] RELATED LINKS

Pharmacology of Antiepileptic Drugs

[edit] BIBLIOGRAPHY

[edit] REFERENCES

  1. http://www.ncbi.nlm.nih.gov/pubmed/17393438
  2. http://www.neurology.org/content/59/10/1573