Flutamide

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Contents

[edit] BRAND NAMES

  • Euflex
  • Eulexin
  • Fluprost
  • Flutamin

[edit] STRUCTURE

Flutamide.jpg

[edit] MECHANISM OF ACTION

Flutamide is a potent non-steroidal antiandrogen drug. It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgen in target tissues or both. Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g. castration.

[edit] INDICATIONS

  • Flutamide is indicated as monotherapy with or without surgical castration and in combination with luteinising hormone-releasing hormone (LHRH) agonist analogues (such as leuprolide acetate) for the treatment of metastatic prostatic carcinoma.
  • Flutamide may be prescribed to treat excess androgen levels in women with PolyCystic Ovarian Syndrome (PCOS), a common cause of hirsutism and acne.

[edit] DOSAGE

[edit] CONTRAINDICATIONS

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Androgens
Agonists Androstanolone   Dihydrotestosterone   Fluoxymesterone   Mesterolone   Methyltestosterone   Testosterone
Antiandrogens Androgen antagonists Bicalutamide   Chlormadinone acetate   Cyproterone acetate   Dienogest   Drospirenone   Flutamide   Nilutamide   Spironolactone
5α reductase inhibitors Dutasteride (Avodart)   Finasteride (Proscar)