BRAND NAMES
 MECHANISM OF ACTION
Flutamide is a potent non-steroidal antiandrogen drug.
It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgen in target tissues or both.
Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g. castration.
- Flutamide is indicated as monotherapy with or without surgical castration and in combination with luteinising hormone-releasing hormone (LHRH) agonist analogues (such as leuprolide acetate) for the treatment of metastatic prostatic carcinoma.
- Flutamide may be prescribed to treat excess androgen levels in women with PolyCystic Ovarian Syndrome (PCOS), a common cause of hirsutism and acne.
 PREGNANCY AND LACTATION
 SIDE EFFECTS
 RELATED LINKS