Carbocisteine

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[edit] BRAND NAMES

[edit] STRUCTURE

Carbocisteine.jpg

[edit] MECHANISM OF ACTION

Carbocisteine is a mucolytic agent. It exerts its action probably by breaking the disulfide bridges of the mucus glycoproteins, favoring expectoration. Carbocisteine should always be accompanied by voluntary efforts to cough to permit expectoration

[edit] INDICATIONS

  • Productive cough
  • Acute and chronic bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport
  • Inflammatory diseases of the rhinopharyngeal tract (i.e. laryngitis, pharyngitis, sinusitis, rhinitis) associated with viscid mucus

[edit] DOSAGE

  • Adults (over the age of 15 years): 750 mg 3 times a day for 5 days (daily doasge is 2250 mg)
  • Children from 2 to 5 years of age: 250 mg twice a day, for 8-10 days
  • Children above 5 years of age: 250 mg 3 times a day, for 8-10 days

[edit] CONTRAINDICATIONS

  • Hypersensitivity to the active substance or to any of the excipients
  • Active peptic ulceration
  • Children under 2 years of age as there is a risk of worsening the airway congestion.

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy: Not recommended during the first trimester of pregnancy
  • Lactation: Carbocisteine is excreted in breast milk. Do not take it if you are breastfeeding.

[edit] SIDE EFFECTS

Gastric discomfort, nausea, diarrhea. If such symptoms occur, it is recommended to reduce the dose.

GI bleeding, skin rashes and anaphylactic reactions have occasionally been reported

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Antitussives / Cough
Cough suppressants Benzonatate   Butamirate   Codeine   Dextromethorphan   Dihydrocodeine   Dropropizine   Levocloperastine   Levodropropizine   Nepinalone   Oxolamine
Mucolytics Acetylcysteine   Ambroxol (Oral)   Bromhexine   Carbocisteine   Erdosteine   Guaifenesin   Neltenexine