Fexofenadine

From Drugs Prescribing Information
Jump to: navigation, search

Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Fexofenadine.jpg

[edit] MECHANISM OF ACTION

Fexofenadine the major active metabolite of the H1 receptor antagonist terfenadine (Withdrawn due to ventricular arrhythmias) is a second generation antihistamine with selective peripheral H1-receptor antagonist activity (it does not cross the blood-brain barrier).

Histamine is a substance that causes allergic symptoms. When histamine (H1) receptors are blocked, histamine cannot have its effect, and this leads to a decrease in the symptoms of allergy.

Fexofenadine is rapidly absorbed (onset of relief < or = 2 hours) and has a long duration of action, making it suitable for once daily administration.

[edit] INDICATIONS

Fexofenadine is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria.

[edit] DOSAGE

  • Adults and Children 12 Years and Older: 60 mg twice daily or 180 mg once daily, before a meal. Do not exceed the recommended dose.
  • Children 6 to 11 years: 30 mg twice daily
  • Children 2 to 5 years: 30 mg twice daily
  • Children 6 months to less than 2 years: 15 mg twice daily

[edit] CONTRAINDICATIONS

  • Known hypersensitivity to Fexofenadine

[edit] PRECAUTIONS

[edit] INTERACTIONS

  • Antacids: Fexofenadine should not be taken closely in time with aluminum and magnesium containing antacids.
  • Fruit juice: Fruit juices such as grapefruit, orange and apple may reduce the bioavailability and exposure of fexofenadine. Take Fexofenadine with water.

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US): Fexofenadine should be used in pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or nursing infant.
  • Nursing Mothers: It is not known if fexofenadine is excreted in human milk. There are no adequate and well-controlled studies in women during lactation. Because many drugs are excreted in human milk, caution should be exercised when fexofenadine hydrochloride is administered to a nursing woman.

[edit] SIDE EFFECTS

The most common adverse reactions are headache, somnolence, dizziness, and stomach discomfort.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES