Fenticonazole

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Contents

[edit] BRAND NAMES

  • Lebanon: Lomexin cream, Lmexin 200 mg ovule, Lomexin 600 mg ovule, lomexin T 1000 mg

[edit] MECHANISM OF ACTION

Fenticonazole is a potent broad-spectrum antimycotic agent. The mechanism of action of fenticonazole is thought to be the blocking of oxidant enzymes with accumulation of peroxides and necrosis of the fungal cell; direct action on the membrane.

[edit] INDICATIONS

Vulvovaginal candidiasis.

[edit] DOSAGE

LOMEXIN CREAM: 5 g should be administered intravaginally every morning and evening for three days.

LOMEXIN VAGINAL OVULES: One 200 mg ovule should be administered intravaginally every evening for three days; alternatively, once only administration of a 600 mg or a 1000 mg ovule should suffice.

It is advisable that the sexual partner is also treated locally (glans and foreskin) with LOMEXIN CREAM, to prevent re-infection.

[edit] CONTRAINDICATIONS

Safety in pregnancy and lactation has not been established.

[edit] PRECAUTIONS

When applied to the lesion or at the time of the intravaginal insertion, a slight burning sensation may be felt which disappears rapidly. The use of topical Fenticonazole, especially if extended, may cause sensitivity to the product. In such case, the treatment should be interrupted and a physician should be consulted to commence an appropriate therapy.

[edit] INTERACTIONS

Fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local administration.

[edit] PREGNANCY AND LACTATION

  • The use of the product during pregnancy is not recommended.
  • Safety in lactation has not been established.

[edit] SIDE EFFECTS

Less frequent: Mild and transient erythematous reactions or burning sensations have been reported only exceptionally and normally disappear rapidly. Allergic reaction may occur less frequently.

In the event of hypersensitivity reactions or the development of resistant microorganisms, treatment should be discontinued.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Antifungals
Ergosterol target : Cell membrane target Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors Imidazoles Topical: Bifonazole   Clotrimazole   Econazole   Fenticonazole   Ketoconazole   Isoconazole   Miconazole   Sertaconazole   Tioconazole
Triazoles Topical: Fluconazole   Terconazole
Systemic: Fluconazole   Itraconazole   Posaconazole   Voriconazole
Polyene antimycotics (ergosterol binding; they form pores in the membrane) Topical: Nystatin
Systemic: Amphotericin B
Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors Topical: Amorolfine   Naftifine   Terbinafine
Systemic: Terbinafine
Echinocandins (β-glucan synthase inhibitors) : Cell wall target Anidulafungin   Caspofungin   Micafungin
Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors Flucytosine
Mitotic inhibitors Griseofulvin
Others Ciclopirox