BRAND NAMES
- Lebanon: Lomexin cream, Lmexin 200 mg ovule, Lomexin 600 mg ovule, lomexin T 1000 mg
 MECHANISM OF ACTION
Fenticonazole is a potent broad-spectrum antimycotic agent. The mechanism of action of fenticonazole is thought to be the blocking of oxidant enzymes with accumulation of peroxides and necrosis of the fungal cell; direct action on the membrane.
LOMEXIN CREAM: 5 g should be administered intravaginally every morning and evening for three days.
LOMEXIN VAGINAL OVULES: One 200 mg ovule should be administered intravaginally every evening for three days; alternatively, once only administration of a 600 mg or a 1000 mg ovule should suffice.
It is advisable that the sexual partner is also treated locally (glans and foreskin) with LOMEXIN CREAM, to prevent re-infection.
Safety in pregnancy and lactation has not been established.
When applied to the lesion or at the time of the intravaginal insertion, a slight burning sensation may be felt which disappears rapidly. The use of topical Fenticonazole, especially if extended, may cause sensitivity to the product. In such case, the treatment should be interrupted and a physician should be consulted to commence an appropriate therapy.
Fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local administration.
 PREGNANCY AND LACTATION
- The use of the product during pregnancy is not recommended.
- Safety in lactation has not been established.
 SIDE EFFECTS
Less frequent: Mild and transient erythematous reactions or burning sensations have been reported only exceptionally and normally disappear rapidly. Allergic reaction may occur less frequently.
In the event of hypersensitivity reactions or the development of resistant microorganisms, treatment should be discontinued.
 RELATED LINKS
|Ergosterol target : Cell membrane target||Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors||Imidazoles||Topical: Bifonazole • Clotrimazole • Econazole • Fenticonazole • Ketoconazole • Isoconazole • Miconazole • Sertaconazole • Tioconazole|
|Triazoles|| Topical: Fluconazole • Terconazole|
Systemic: Fluconazole • Itraconazole • Posaconazole • Voriconazole
|Polyene antimycotics (ergosterol binding; they form pores in the membrane)|| Topical: Nystatin |
Systemic: Amphotericin B
|Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors|| Topical: Amorolfine • Naftifine • Terbinafine |
|Echinocandins (β-glucan synthase inhibitors) : Cell wall target||Anidulafungin • Caspofungin • Micafungin|
|Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors||Flucytosine|