BRAND NAMES
- Famodil (Italy)
- Gastridin (Italy)
- Pepcid (U.S.) PI
 MECHANISM OF ACTION
Famotidine competes with histamine for binding at H2-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in the reduction of gastric acid secretions and, hence, pepsin secretions. Famotidine also decreases gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin.
- Treatment and maintenance therapy of duodenal ulcer
- Treatment of gastric ulcer, gastroesophageal reflux disease (GERD), and pathological hypersecretory conditions (e.g., Zollinger-Ellison Syndrome, multiple endocrine adenomas).
- Famotidine is also given to some patients taking NSAIDs to prevent peptic ulcers
- Duodenal Ulcer:
- Acute duodenal ulcer therapy, 40 mg once a day at bedtime for 4 weeks.
- Maintenance Therapy, 20 mg once a day at bedtime.
- Gastric ulcer: 40 mg once a day at bedtime
- Gastroesophageal Reflux Disease (GERD): 20 mg twice a day for up to 6 weeks
- Pathological Hypersecretory Conditions (e.g., Zollinger-Ellison Syndrome, Multiple Endocrine Adenomas): usually the starting dose is 20 mg every 6 hours, then dosage should be adjusted to individual patient needs.
Patients with a history of hypersensitivity to other H2-receptor antagonists.
 WARNINGS AND PRECAUTIONS
Symptomatic response to therapy with Famotidine does not preclude the presence of gastric malignancy.
Unlike cimetidine, the first H2 antagonist, famotidine has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other drugs.
 PREGNANCY AND LACTATION
 SIDE EFFECTS
Side effects associated with famotidine use include headache, dizziness, and constipation or diarrhea
 RELATED LINKS
|Heartburn/Gastritis/Gastric ulcer/Duodenal ulcer/Gastroesophageal reflux|
|H2 antagonists||Famotidine • Nizatidine • Ranitidine (Zantac)|
|Proton-pump inhibitors||Dexlansoprazole (Dexilant) • Esomeprazole (Nexium) • Lansoprazole (Prevacid) • Omeprazole (Losec, Prilosec) • Omeprazole/Sodium bicarbonate (Zegerid) • Pantoprazole (Controloc, Pantecta, Pantoloc, Protonix) ( • Rabeprazole (Aciphex, Pariet)|
|Other drugs||Alginic acid • Magaldrate • Sucralfate|
|Combination Regimens||Bismuth Subcitrate Potassium/Metronidazole/Tetracycline (Pylera) • Lansoprazole/Amoxicillin/Clarithromycin (Prevpac)|