BRAND NAMES
 MECHANISM OF ACTION
Naftifine inhibits squalene epoxidase, this results in deceased synthesis of ergosterol and accumulation of toxic squalene. Ergosterol is an essential component of the fungal cell membrane. The inhibition of its synthesis results in accumulation of toxic 14α-methylated sterols and the production of a defective cell membrane with altered permeability and leakage of cellular contents (fungicidal effect).
- Treatment of a wide range of superficial dermatomycoses such as, ringworm (tinea corporis), athlete's foot (tinea pedis), and jock itch (tinea cruris)
Apply a thin layer of naftifine cream once or twice daily to the affected areas and to the surrounding healthy skin for 2 weeks
If redness or irritation develops, treatment should be discontinued
 PREGNANCY AND LACTATION
- Pregnancy Category B (US). Topical Naftifine cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when topical Naftifine is administered to a nursing woman.
 SIDE EFFECTS
The most common adverse reaction (≥1%) is pruritus.
 RELATED LINKS
|Ergosterol target : Cell membrane target||Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors||Imidazoles||Topical: Bifonazole • Clotrimazole • Econazole • Fenticonazole • Ketoconazole • Isoconazole • Miconazole • Sertaconazole • Tioconazole|
|Triazoles|| Topical: Fluconazole • Terconazole|
Systemic: Fluconazole • Itraconazole • Posaconazole • Voriconazole
|Polyene antimycotics (ergosterol binding; they form pores in the membrane)|| Topical: Nystatin |
Systemic: Amphotericin B
|Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors|| Topical: Amorolfine • Naftifine • Terbinafine |
|Echinocandins (β-glucan synthase inhibitors) : Cell wall target||Anidulafungin • Caspofungin • Micafungin|
|Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors||Flucytosine|