Naftifine

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[edit] BRAND NAMES

[edit] STRUCTURE

Naftifine.jpg

[edit] MECHANISM OF ACTION

Naftifine inhibits squalene epoxidase, this results in deceased synthesis of ergosterol and accumulation of toxic squalene. Ergosterol is an essential component of the fungal cell membrane. The inhibition of its synthesis results in accumulation of toxic 14α-methylated sterols and the production of a defective cell membrane with altered permeability and leakage of cellular contents (fungicidal effect).

[edit] INDICATIONS

  • Treatment of a wide range of superficial dermatomycoses such as, ringworm (tinea corporis), athlete's foot (tinea pedis), and jock itch (tinea cruris)

[edit] DOSAGE

Apply a thin layer of naftifine cream once or twice daily to the affected areas and to the surrounding healthy skin for 2 weeks

[edit] CONTRAINDICATIONS

None

[edit] PRECAUTIONS

If redness or irritation develops, treatment should be discontinued

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category B (US). Topical Naftifine cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when topical Naftifine is administered to a nursing woman.

[edit] SIDE EFFECTS

The most common adverse reaction (≥1%) is pruritus.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Antifungals
Ergosterol target : Cell membrane target Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors Imidazoles Topical: Bifonazole   Clotrimazole   Econazole   Fenticonazole   Ketoconazole   Isoconazole   Miconazole   Sertaconazole   Tioconazole
Triazoles Topical: Fluconazole   Terconazole
Systemic: Fluconazole   Itraconazole   Posaconazole   Voriconazole
Polyene antimycotics (ergosterol binding; they form pores in the membrane) Topical: Nystatin
Systemic: Amphotericin B
Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors Topical: Amorolfine   Naftifine   Terbinafine
Systemic: Terbinafine
Echinocandins (β-glucan synthase inhibitors) : Cell wall target Anidulafungin   Caspofungin   Micafungin
Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors Flucytosine
Mitotic inhibitors Griseofulvin
Others Ciclopirox