Tranexamic acid

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Tranexamic Acid belongs to a group of medicines called anti-fibrinolytic agents, which are used to stop or reduce unwanted bleeding.

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[edit] BRAND NAMES

[edit] STRUCTURE

Tranexamic acid.jpg

[edit] MECHANISM OF ACTION

Tranexamic acid is a synthetic lysine amino acid derivative, It is an antifibrinolytic which diminishes the dissolution of hemostatic fibrin by plasmin. In the presence of tranexamic acid, the lysine receptor binding sites of plasmin for fibrin are occupied, preventing binding to fibrin monomers, thus preserving and stabilizing fibrin’s matrix structure.

[edit] INDICATIONS

Tranexamic acid is useful in a wide range of haemorrhagic conditions:

  • Heavy menstrual bleeding
  • Nose bleeds (epistaxis)
  • Cervical surgery
  • Bleeding inside the eye (traumatic hyphaema)
  • A hereditary disease called angioneurotic edema
  • Dentistry: Tranexamic acid is indicated in patients with hemophilia for short-term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction

[edit] DOSAGE

  • Tablets: 1300 mg (two 650 mg tablets) three times a day (3,900 mg/day) for a maximum of 5 days during monthly menstruation
  • Injection:
    • Dentistry: Immediately before tooth extraction in patients with hemophilia, administer 10 mg per kg body weight intravenously. Following tooth extraction, intravenous therapy, at a dose of 10 mg per kg body weight three to four times daily, may be used for 2 to 8 days.

[edit] CONTRAINDICATIONS

  • Active thromboembolic disease or a history or intrinsic risk of thrombosis or thromboembolism, including retinal vein or artery occlusion
  • Hypersensitivity to tranexamic acid

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category B (US). Tranexamic acid should be used during pregnancy only if clearly needed.
  • Nursing Mothers: Tranexamic acid should be used during lactation only if clearly needed

[edit] SIDE EFFECTS

Tranexamic acid is well tolerated; Possible side effects include: Gastrointestinal disturbances (nausea, vomiting, diarrhea), headache, sinus and nasal symptoms, back pain, abdominal pain, musculoskeletal pain, joint pain, muscle cramps, migraine, anemia, fatigue and thromboembolic events.

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