Levothyroxine

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

File:Levothyroxine.jpg

[edit] MECHANISM OF ACTION

[edit] INDICATIONS

  • Hypothyroidism: As replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis.
  • Pituitary TSH suppression in the treatment and prevention of euthyroid goiters (abnormal enlargement of the thyroid gland) and in the management of thyroid cancer

[edit] DOSAGE

[edit] CONTRAINDICATIONS

  • Thyrotoxicosis
  • Acute myocardial infarction
  • Patients with uncorrected adrenal insufficiency since thyroid hormones may precipitate an acute adrenal crisis by increasing the metabolic clearance of glucocorticoids

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

  • General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating.
  • Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia.
  • Cardiovascular: Palpitations, tachycardia, angina, cardiac arrest
  • Dermatologic: Allergic skin reactions, partial loss of hair in first few months of therapy in children
  • Gastrointestinal: diarrhea, vomiting, abdominal cramps and elevations in liver function tests
  • Endocrine: decreased bone mineral density;
  • Reproductive: menstrual irregularities, impaired fertility

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

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