Erdosteine

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[edit] BRAND NAMES

[edit] STRUCTURE

Erdosteine.jpg

[edit] MECHANISM OF ACTION

Erdosteine is a multimechanism, mucolytic agent that decreases the sputum viscoelastic properties. In addition to its mucolytic properties on bronchial mucus thus facilitating expectoration, it shows effects in antagonizing the local formation of free radicals.

Pharmacological studies have demonstrated that Erdosteine does not possess these properties as such, but it is active only after metabolization. In fact, the SH groups, to which the activity is ascribed, are chemically blocked and become free only after metabolization or in alkaline environment.

[edit] INDICATIONS

Mucolytic agent in acute and chronic respiratory diseases.

[edit] DOSAGE

300 mg capsule: 1 capsule 2-3 times a day orally

[edit] CONTRAINDICATIONS

  • Known hypersensitivity to Erdosteine
  • Patients with active peptic ulcer.
  • Because of a possible interference of the product metabolites with the methionine metabolism, Erdosteine is contraindicated in patients suffering from hepatic cirrhosis and deficiency of the cystathionine-synthetase enzyme.

[edit] PRECAUTIONS

None

[edit] INTERACTIONS

No harmful interactions with other drugs have been reported

[edit] PREGNANCY AND LACTATION

The safety of erdosteine in pregnancy has not been established, therefore, its use is not recommended. Equally, its use is not recommended during lactation.

[edit] SIDE EFFECTS

Nervous system disorders 
Very rare (<1/10,000) 
Headache
Respiratory, thoracic and mediastinal disorders 
Very rare (<1/10,000)
Dyspnoea
Gastrointestinal disorders 
Very rare (<1/10,000) 
Taste alterations, nausea, 
vomiting, diarrhoea, epigastric 
pain
Dermatological disorders 
Very rare (<1/10,000)
Urticaria, erythema, eczema

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Antitussives / Cough
Cough suppressants Benzonatate   Butamirate   Codeine   Dextromethorphan   Dihydrocodeine   Dropropizine   Levocloperastine   Levodropropizine   Nepinalone   Oxolamine
Mucolytics Acetylcysteine   Ambroxol (Oral)   Bromhexine   Carbocisteine   Erdosteine   Guaifenesin   Neltenexine