Adapalene/Benzoyl peroxide

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

[edit] MECHANISM OF ACTION

Adapalene, is a synthetic retinoid, It binds to retinoic acid receptors found predominantly in the terminal differentiation zone of epidermis and acts as a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Adapalene is more active than tretinoin in modulating cellular differentiation.

Benzoyl peroxide is an antibacterial agent which has been shown to be effective against Propionibacterium acnes. This action is believed to be responsible for its usefulness in acne.
Benzoyl peroxide, exerts also a desquamative action and provides mild peeling and keratolytic activity.

[edit] INDICATIONS

Topical treatment of acne vulgaris

[edit] DOSAGE

Apply a thin film to affected areas once daily after washing. Use a pea-sized amount for each area of the face (e.g., forehead, chin, each cheek).

[edit] CONTRAINDICATIONS

  • Hypersensitivity to adapalene or to Benzoyl peroxide

[edit] PRECAUTIONS

  • Avoid exposure to sunlight and sunlamps. Wear sunscreen when sun exposure cannot be avoided
  • Avoid contact with the eyes, lips, angles of the nose, and mucous membranes
  • Erythema, dryness, scaling, burning, or pruritus may be experienced. These are most likely to occur during the first two to four weeks of treatment and usually lessen with continued use of the medication. Depending upon the severity of these side effects, patients should be instructed to reduce the frequency of application or discontinue the drug.

[edit] INTERACTIONS

Concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices or lime rind) should be approached with caution.

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US). Adapalene/Benzoyl_peroxide combination should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Nursing Mothers: It is not known whether adapalene or benzoyl peroxide is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Adapalene/Benzoyl_peroxide combination is administered to a nursing woman.

[edit] SIDE EFFECTS

Most commonly reported adverse events are dry skin, contact dermatitis, application site burning, application site irritation and skin irritation.

[edit] RELATED LINKS

Acne Treatments

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Acne
Oral antibiotics Clindamycin (Oral route)   Doxycycline   Erythromycin (Oral route)   Josamycin   Lymecycline   Minocycline   Tetracycline
Topical antibiotics Clindamycin (Topical)   Erythromycin (Topical)
Topical retinoids Adapalene   Tazarotene   Tretinoin
Oral retinoids Isotretinoin (Oral)
Oral contraceptives Estradiol valerate/Dienogest   Ethinyl Estradiol/Cyproterone acetate
Topical Antibacterial/Keratolytic Benzoyl peroxide   Hydrogen Peroxide Cream
Topical combination products Clindamycin/Benzoyl peroxide   Adapalene/Benzoyl peroxide   Clindamycin/Tretinoin   Miconazole/Benzoyl peroxide   Erythromycin/Benzoyl peroxide   Erythromycin/Isotretinoin