Budesonide (Nasal spray)

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[edit] BRAND NAMES

[edit] STRUCTURE

Budesonide.jpg

[edit] MECHANISM OF ACTION

Budesonide is a synthetic corticosteroid having potent glucocorticoid activity and weak mineralocorticoid activity. Corticosteroids have a wide range of inhibitory activities against multiple cell types (e.g. mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators(e.g. histamine, eicosanoids, leukotrienes, and cytokines) involved in allergic mediated inflammation.

[edit] INDICATIONS

  • Seasonal or perennial allergic rhinitis in adults and children six years of age and older. Budesonide provides significant reduction in the severity of nasal symptoms including runny nose, sneezing, and nasal congestion.
  • Nasal Polyps (small masses of tissue that grow from the nose lining)

[edit] DOSAGE

  • Adults and children 6 years of age and older:
  • Treatment: The usual dose is 128-200 mcg into each nostril once daily in the morning, or 64-100 mcg into each nostril morning and evening.
  • Maintenance: 32-100mcg in each nostril, once daily

Improvement can occur within 24 hours of initiating the treatment, but it may take 2 weeks to achieve maximum benefit.

[edit] CONTRAINDICATIONS

  • Hypersensitivity to any of the ingredients of the preparation

[edit] PRECAUTIONS

  • Intranasal corticosteroids may cause a reduction in growth velocity when administered to pediatric patients
  • Budesonide Nasal spray has an inhibitory effect on nasal wound healing. Do not use it until healing has occurred.

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US). Budesonide Spray should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Nursing Mothers: It is not known whether budesonide is excreted in human milk. Caution should be exercised if administered to nursing women.

[edit] SIDE EFFECTS

Adverse events include: Sneezing after spraying or irritated nose, nose bleeding, dry nose, nasal crust, itching or sore throught, cough, dizziness, tiredness and headache

Rare adverse events include: nasal septum perforation, pharynx disorders (throat irritation, throat pain, swollen throat, burning throat, and itchy throat), angioedema, anosmia (inability to perceive odor), palpitations and development of localized infections of the nose and pharynx with Candida albicans.

[edit] RELATED LINKS

[edit] REFERENCES