Econazole (topical)

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Contents

[edit] BRAND NAMES

Bangladesh: Ecoderm


Econazole/Triamcinolone: Pevisone

[edit] STRUCTURE

Econazole.jpg

[edit] MECHANISM OF ACTION

Econazole is an antifungal agent of the imidazole class. It inhibits lanosterol 14α-demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol.

Ergosterol is an essential component of the fungal cell membrane. The inhibition of its synthesis results in accumulation of toxic 14α-methylated sterols and the production of a defective cell membrane with altered permeability and leakage of cellular contents.

[edit] INDICATIONS

Treatment of infections caused by susceptible dermatophyte and candida species including tinea pedis (athlete's foot), tinea cruris, tinea corporis (ringworm), tinea versicolor (pityriasis versicolor) and cutaneous candidiasis.

[edit] DOSAGE

Apply twice daily, in the morning and evening. The cream should be massaged gently into the affected and surrounding skin areas. Clinical improvement usually occurs promptly; however, complete disappearance of the symptoms of the disease may require prolonged treatment Candida infections should be treated for at least two weeks and dermatophyte infections for one month to reduce the risk of recurrence. If no improvement has occurred after one month of treatment, the diagnosis should be reassessed.

[edit] CONTRAINDICATIONS

  • Hypersensitivity to econazole

[edit] PRECAUTIONS

If marked irritation or sensitization should occur, discontinue therapy.

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US). Econazole should be used in the first trimester of pregnancy only when the physician considers it essential to the welfare of the patient. The drug should be used during the second and third trimesters of pregnancy only if clearly needed.
  • Nursing Mothers: It is not known whether econazole is excreted in human milk. Caution should be exercised if Econazole (Topical) is administered to a nursing woman.

[edit] SIDE EFFECTS

Econazole (Topical) is usually well tolerated. Adverse effects are limited to occasional local skin irritation manifested by erythema, pruritus, and burning or stinging sensation; cessation of therapy is rarely warranted.

[edit] RELATED LINKS

Azoles mechanism of action

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Antifungals
Ergosterol target : Cell membrane target Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors Imidazoles Topical: Bifonazole   Clotrimazole   Econazole   Fenticonazole   Ketoconazole   Isoconazole   Miconazole   Sertaconazole   Tioconazole
Triazoles Topical: Fluconazole   Terconazole
Systemic: Fluconazole   Itraconazole   Posaconazole   Voriconazole
Polyene antimycotics (ergosterol binding; they form pores in the membrane) Topical: Nystatin
Systemic: Amphotericin B
Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors Topical: Amorolfine   Naftifine   Terbinafine
Systemic: Terbinafine
Echinocandins (β-glucan synthase inhibitors) : Cell wall target Anidulafungin   Caspofungin   Micafungin
Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors Flucytosine
Mitotic inhibitors Griseofulvin
Others Ciclopirox