BRAND NAMES
 MECHANISM OF ACTION
Econazole is an antifungal agent of the imidazole class. It inhibits lanosterol 14α-demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol.
Ergosterol is an essential component of the fungal cell membrane. The inhibition of its synthesis results in accumulation of toxic 14α-methylated sterols and the production of a defective cell membrane with altered permeability and leakage of cellular contents.
Treatment of infections caused by susceptible dermatophyte and candida species including tinea pedis (athlete's foot), tinea cruris, tinea corporis (ringworm), tinea versicolor (pityriasis versicolor) and cutaneous candidiasis.
Apply twice daily, in the morning and evening. The cream should be massaged gently into the affected and surrounding skin areas. Clinical improvement usually occurs promptly; however, complete disappearance of the symptoms of the disease may require prolonged treatment Candida infections should be treated for at least two weeks and dermatophyte infections for one month to reduce the risk of recurrence. If no improvement has occurred after one month of treatment, the diagnosis should be reassessed.
- Hypersensitivity to econazole
If marked irritation or sensitization should occur, discontinue therapy.
 PREGNANCY AND LACTATION
- Pregnancy Category C (US). Econazole should be used in the first trimester of pregnancy only when the physician considers it essential to the welfare of the patient. The drug should be used during the second and third trimesters of pregnancy only if clearly needed.
- Nursing Mothers: It is not known whether econazole is excreted in human milk. Caution should be exercised if Econazole (Topical) is administered to a nursing woman.
 SIDE EFFECTS
Econazole (Topical) is usually well tolerated. Adverse effects are limited to occasional local skin irritation manifested by erythema, pruritus, and burning or stinging sensation; cessation of therapy is rarely warranted.
 RELATED LINKS
|Ergosterol target : Cell membrane target||Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors||Imidazoles||Topical: Bifonazole • Clotrimazole • Econazole • Fenticonazole • Ketoconazole • Isoconazole • Miconazole • Sertaconazole • Tioconazole|
|Triazoles|| Topical: Fluconazole • Terconazole|
Systemic: Fluconazole • Itraconazole • Posaconazole • Voriconazole
|Polyene antimycotics (ergosterol binding; they form pores in the membrane)|| Topical: Nystatin |
Systemic: Amphotericin B
|Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors|| Topical: Amorolfine • Naftifine • Terbinafine |
|Echinocandins (β-glucan synthase inhibitors) : Cell wall target||Anidulafungin • Caspofungin • Micafungin|
|Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors||Flucytosine|