Ebastine

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Ebastine (Ebastel, Kestine) is a long-acting and selective H1-histamine receptor antagonist with low potential for causing drowsiness, indicated mainly for allergic rhinitis and chronic idiopathic urticaria

Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Ebastine.jpg

[edit] MECHANISM OF ACTION

Ebastine is a long-acting and selective H1-histamine receptor antagonist with low potential for causing drowsiness.

Ebastine does not penetrate the blood-brain barrier, and so provoke minimal central nervous system (CNS) effects, i.e. seldom causing sedation or drowsiness.

[edit] INDICATIONS

Ebastine is indicated for the symptomatic treatment of:

  • Seasonal and perennial allergic rhinitis
  • Idiopathic chronic urticaria

[edit] DOSAGE FORMS AND STRENGTHS

  • 10 and 20 mg tablets
  • 10 mg fast-dissolving tablets
  • Pediatric syrup

[edit] DOSAGE

Ebastine may be taken with or without food.

  • Allergic rhinitis and Urticaria:
    • Children 12 years and above and adults: 10 mg once daily
    • Children from 6 to 11 years old: 5 mg once daily.
    • Children from 2 to 5 years old: 2.5 mg once daily.


  • Severe symptoms of Allergic rhinitis:
    • Children 12 years and above and adults: 20 mg once daily

[edit] CONTRAINDICATIONS

  • Patients with a known hypersensitivity to ebastine.
  • Pregnancy and lactation.

[edit] WARNINGS AND PRECAUTIONS

Ebastine reaches its therapeutic effect 1 to 3 hours after administration. It must not be used in urgent acute allergic cases

Use with caution in patients known to have the following conditions:

  • Long QT syndrome
  • Hypokalemia
  • Treatment with any medicine known to produce an increase in QT interval
  • Treatment with any medicine known to inhibit CYP3A4 (azole antifungals and macrolide antibiotics).
  • Ebastine lacks significant sedative effects. Patients should, however, be warned that a small number of individuals may experience sedation. It is therefore advisable to determine individual response before driving or performing complicated tasks. This effect may be compounded by the simultaneous intake of alcohol or other central nervous system depressants.

[edit] PREGNANCY AND LACTATION

  • Pregnancy: The safety of ebastine during pregnancy and lactation has not been established. For this reason, it should be taken during pregnancy only if the doctor considers that the expected benefit outweighs the possible risks.
  • Lactation: It is not known whether ebastine passes into mother’s milk. Ebastine should not be taken during lactation

[edit] SIDE EFFECTS

Common side effects (affect 1 to 10 users in 100):

  • Headache
  • Drowsiness.
  • Dry mouth.

Uncommon side effects (affect 1 to 10 users in 1,000):

  • Sore throat (pharyngitis), runny nose (rhinitis), nose bleeds.
  • Abdominal pain, nausea, indigestion.
  • Weakness (asthenia), dizziness, insomnia.

Very rare side effects (affect less than 1 user in 10,000):

  • Nervousness.
  • Disturbed sense of touch.
  • Palpitations, accelerated pulse.
  • Vomiting.
  • Abnormal liver function test.
  • Rash, nettle rash, eczema.
  • Menstrual disorders.
  • edema.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES