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 BRAND NAMES
 MECHANISM OF ACTION
Timolol and travoprost lower intraocular pressure by complementary mechanisms of action and the combined effect results in additional IOP reduction compared to either compound alone.
- Travoprost, is a prostaglandin F2α analogue. In the eye, prostaglandin increases the drainage of the watery fluid (aqueous humour) out of the eyeball. Travatan acts in the same way and increases the outflow of aqueous humour via trabecular meshwork and uveoscleral pathways. This helps to reduce the intraocular pressure.
- Timolol is a nonselective beta-blocker that works by lowering the intraocular pressure by reducing the production of aqueous humor within the eye.
Raised pressure in the eye causes damage to the retina and to the optic nerve that sends signals from the eye to the brain. This can result in serious vision loss and even blindness. By lowering the pressure, Travoprost and Timolol reduce the risk of damage.
Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma who are insufficiently responsive to topical beta-blockers or prostaglandin analogues alone.
The dose is one drop of Timolol/Travoprost in the conjunctival sac of the affected eye(s) once daily, in the morning or evening.
When using nasolacrimal occlusion or closing the eyelids gently, the systemic absorption is reduced. This may result in a decrease in systemic side effects and an increase in local activity
Remove contact lenses prior to application and wait 15 minutes after instillation of the dose before reinsertion
- Hypersensitivity to any component
- Bronchial asthma or with a history of bronchial asthma, or severe chronic obstructive pulmonary disease
- Sinus bradycardia; second and third degree atrioventricular block; overt cardiac failure; cardiogenic shock
 WARNINGS AND PRECAUTIONS
- Pigmentation: Travoprost may gradually change the eye colour by increasing the number of melanosomes (pigment granules) in melanocytes. This change may be permanent.
- Eyelash changes: Travoprost may increase the length, thickness, colour and/or number of eyelashes and may cause unusual hair growth on your eyelids. eyelash changes are usually reversible.
 PREGNANCY AND LACTATION
- Timolol/Travoprost combination should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- The use of Timolol/Travoprost combination by breastfeeding mothers is not recommended.
 SIDE EFFECTS
Reported treatment-related undesirable effect include: conjunctival hyperemia (Usually mild), visual acuity, eye discomfort, foreign body sensation, pain and pruritus, iris hyperpigmentation, periocular hyperpigmentation, headache, dizziness, nervousness, Bradycardia and Bronchospasm (predominantly in patients with pre-existing bronchospastic disease).
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