Disulfiram

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

File:Disulfiram.jpg

[edit] MECHANISM OF ACTION

Disulfiram interferes with the normal metabolic degradation of alcohol in the body, resulting in an increased concentration of acetaldehyde in the blood. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms within about 10 minutes following alcohol intake. These symptoms are accompanied by pronounced discomfort and persist until the alcohol is eliminated. Reactions to alcohol may occur up to 14 days following withdrawal of disulfiram.

The marked unpleasantness of an Disulfiram-alcohol reaction acts as a form of aversion treatment. Consequently, the regular administration of Disulfiram permits the effective treatment of chronic alcoholics as outpatients.

[edit] INDICATIONS

As an adjunct in the treatment of chronic alcoholism.

[edit] DOSAGE

[edit] CONTRAINDICATIONS

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES