Loperamide

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Loperamide.jpg

[edit] MECHANISM OF ACTION

Loperamide is an orally administered, noncentrally acting antidiarrheal agent. Loperamide binds to the opiate receptor in the gut wall. Consequently, it inhibits the release of acetylcholine and prostaglandins, thereby reducing peristalsis, and increasing intestinal transit time

[edit] INDICATIONS

Symptomatic treatment of acute diarrhea and for relief of chronic diarrhea associated with inflammatory bowel disease.

[edit] DOSAGE

Adults and children aged 12 and over: 4 mg to begin with and then 2 mg after each episode of diarrhea. Maximum daily dose is 16 mg.

[edit] CONTRAINDICATIONS

Hypersensitivity to loperamide }children under the age of 12 years old

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C. Loperamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Nursing Mothers> Small amounts of loperamide may appear in human breast milk. Therefore, it is not recommended during breast-feeding.

[edit] SIDE EFFECTS

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES