Disease-modifying antirheumatic drugs

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Drug Mechanism
Synthetic small molecules
Hydroxychloroquine (Plaquenil) Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and decrease chemotaxis
Azathioprine (Imuran) Purine synthesis inhibitor
Cyclosporine (Neoral, Sandimmune) Calcineurin inhibitor
Leflunomide (Arava) Pyrimidine synthesis inhibitor
Methotrexate (Rheumatrex , Trexall) Purine metabolism inhibitor
Sulfasalazine (Azulfidine) Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and increase chemotactic factors
cyclophosphamide
Biologic
TNF-alpha inhibitors
Etanercept (Enbrel)
Adalimumab (Humira)
Infliximab (Remicade)
Golimumab (Simponi)
Certolizumab pegol (Cimzia)
T-cell Costimulatory Blocking  Agents Abatacept (Orencia)
B-cell Depleting Agents Rituximab (Rituxan)
IL-1 Receptor Antagonist Anakinra (Kineret)