Dimetindene (Oral route)

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[edit] BRAND NAMES

[edit] STRUCTURE

Dimetindene.jpg

[edit] MECHANISM OF ACTION

Dimetindene is an histamine H1 antagonist/anticholinergic used orally and locally as an antipruritic.

[edit] INDICATIONS

Symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies; pruritus of various origins, except pruritus due to cholestasis; insect bites. Dimetindene is also indicated for pruritus in eruptive skin diseases such as chicken-pox.

Dimetindene can be as an adjuvant in eczema and other pruriginous dermatoses of allergic origin.

[edit] DOSAGE

  • 1 mg tablets: For adults, a typical dose might be 1-2 tablets , 3 times a day.
  • 1 mg/mL Drops:
    • Infants up to 1 year, 3-10 drops 3 times a day.
    • Infants of 1 to 3 years, 10-15 drops 3 times a day.
    • Children over 3 years, 15-20 drops 3 times a day.
    • Adults, 20-40 drops 3 times a day.

[edit] CONTRAINDICATIONS

  • Hypersensitivity to dimetindene.

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

The most common side effect associated with Dimetindene was drowsiness. Occasionally, nausea and gastrointestinal discomfort, dryness of the mouth and throat, vertigo, excitation, and headaches were observed.

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[edit] BIBLIOGRAPHY

[edit] REFERENCES