Digoxin

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Contents

[edit] BRAND NAMES

  • Lanoxin

[edit] STRUCTURE

Digoxin.jpg

[edit] MECHANISM OF ACTION

Digoxin is a cardiac glycoside similar to Digitoxin. Digoxin inhibits the Na+/K+ ATPase membrane pump of heart cells, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin).

Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential

[edit] INDICATIONS

  • Treatment of mild to moderate heart failure (ACE inhibitors are considered the first choice for congestive heart failure)
  • Control of ventricular rate in the treatment of chronic atrial fibrillation (Digoxin can reduce the ventricular rate).

[edit] DOSAGE

[edit] CONTRAINDICATIONS

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

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