BRAND NAMES
- Europe: Neoclarityn PI, Dasselta PI
- International: Aerius
- Italy: Aerius, Azomyr
- UK: Neoclarityn
- U.S.: Clarinex PI
 MECHANISM OF ACTION
Desloratadine is long-acting tricyclic second generation (non-sedating) antihistamine. It is the active metabolite of loratadine and produces the same pharmacologic effect; both antagonist at peripheral histamine (H1) receptors. Histamine is a substance that causes allergic symptoms. When histamine (H1) receptors are blocked, histamine cannot have its effect, and this leads to a decrease in the symptoms of allergy.
As with other second-generation antihistamines, the low incidence of sedation can be attributed to reduced penetration into the CNS
- Chronic Idiopathic Urticaria
- Seasonal and perennial allergic rhinitis to relief symptoms such as sneezing, rhinorrhea and nasal pruritus, occular pruritus and tearing.
- Adults and Adolescents 12 Years of Age and Over: 5 mg once daily with or without a meal
- Children 6 to 11 Years of Age: 2.5 mg once daily with or without a meal
- Children 12 Months to 5 Years of Age: 1.25 mg once daily with or without a meal
- Children 6 to 11 Months of Age: 1 mg once daily with or without a meal (FDA approved)
Hypersensitivity to desloratadine or to loratadine.
 WARNINGS AND PRECAUTIONS
- Somnolence has been reported very rarely in patients taking Desloratadine. Caution should be exercised when driving a car or operating potentially dangerous machinery.
- Rare cases of hypersensitivity reactions (such as rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis) have been reported. In such cases, stop the drug at once and consider alternative treatments.
No clinically relevant interactions were observed in clinical trials with desloratadine tablets in which erythromycin or ketoconazole were co-administered.
In a clinical pharmacology trial Desloratadine taken concomitantly with alcohol did not potentiate the performance impairing effects of alcohol.
 PREGNANCY AND LACTATION
- Pregnancy Category C (US). Desloratadine should be used during pregnancy only if clearly needed.
- Desloratadine passes into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue desloratadine, taking into account the benefit of the drug to the nursing mother and the possible risk to the child.
 SIDE EFFECTS
Most common adverse reactions were dry mouth, myalgia, fatigue, dizziness, somnolence, headache and dysmenorrhea (menstrual pain)
 RELATED LINKS
|For systemic use||Bilastine • Cetirizine • Chlorphenamine • Cyproheptadine • Dexchlorpheniramine • Desloratadine • Dimetindene (Oral route) • Ebastine • Fexofenadine • Ketotifen (Oral route) • Levocetirizine • Loratadine • Mequitazine • Mizolastine • Oxatomide (Oral route) • Rupatadine|
|For topical use||Dexchlorpheniramine (Topical) • Diphenhydramine • Dimetindene (Topical) • Oxatomide (Topical) • Promethazine|
|Nasal spray||Azelastine (Nasal spray) • Levocabastine (Nasal spray)|
|Eye drops||Azelastine (Eye drops) • Epinastine • Ketotifen (Eye drops) • Levocabastine (Eye drops) • Olopatadine (Eye drops)|
|Combinations||Cetirizine/Pseudoephedrine • Desloratadine/Pseudoephedrine|