BRAND NAMES
- International: Deramaxx
 MECHANISM OF ACTION
Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class. It is a selective inhibitor of the cyclooxygenase 2 enzyme (COX-2).
Two forms of cyclooxygenase have been described in mammals:
- The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function.
- The inducible cyclooxygenase, COX-2, is responsible for the production of mediators including PGE2 which induce pain, inflammation or fever..
Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 reduces pain and inflammation associated with musculoskeletal disorders. At doses of 2-4 mg/kg/day, Deracoxib tablets do not inhibit COX-1 based on in vitro studies using cloned canine cyclooxygenase. The clinical relevance of this in vitro data has not been shown.
- Control of pain and inflammation associated with osteoarthritis in dogs.
- Control of postoperative pain and inflammation associated with orthopedic surgery in dogs.
- Postoperative Dental Pain and Inflammation
Use the lowest effective dose for the shortest duration consistent with individual response. postprandial administration is preferable
- Osteoarthritis Pain and Inflammation: 0.45 – 0.91 mg/lb/day (1 to 2 mg/kg/day) as a single daily dose, as needed.
- Postoperative Orthopedic Pain and Inflammation: 1.4 – 1.8 mg/lb/day (3 to 4 mg/kg/day) as a single daily dose, as needed, not to exceed 7 days of administration
- Postoperative Dental Pain and Inflammation: 0.45 – 0.91 mg/lb/day (1 to 2 mg/kg/day) as a single daily dose, for 3 days. The first dose should be given approximately 1 hour prior to dental surgery and subsequent doses should be given daily for up to two additional treatments.
hypersensitivity to deracoxib
- Since NSAIDs possess the potential to produce gastrointestinal ulceration and/or perforation, concomitant use of Deracoxib tablets with other anti-inflammatory drugs, such as NSAIDs or corticosteroids, should be avoided.
 PREGNANCY AND LACTATION
The safe use of Deracoxib tablets in pregnant or lactating dogs has not been evaluated.
 SIDE EFFECTS
Adverse reactions may include vomiting, diarrhea, decreased appetite, dark or tarry stools, increased water consumption, increased urination, anemia, yellowing of gums, skin or white of the eye due to jaundice, lethargy, incoordination, seizure, or behavioral changes.
Serious adverse reactions associated with this drug class can occur without warning and in some cases result in death
 RELATED LINKS
|Non-steroidal anti-inflammatory drugs (NSAIDs)|
|Non-selective (COX-1 and COX-2 inhibitors)||Aceclofenac • Acetylsalicylic acid • Benzydamine • Diclofenac • Flurbiprofen • Ibuprofen • Indometacin • Ketoprofen • Ketorolac • Ketorolac • Lornoxicam • Mefenamic acid • Morniflumate • Nabumetone • Naproxen • Niflumic acid • Piroxicam • Tenoxicam|
|Relatively COX-2 selective||Meloxicam • Nimesulide|
|COX-2 selective inhibitors (Coxibs)||Celecoxib • Etoricoxib • Parecoxib|
|Ophthalmic NSAIDs||Bromfenac (ophthalmic) • Diclofenac (ophthalmic) • Flurbiprofen (ophthalmic) • Ketorolac (ophthalmic) • Nepafenac (ophthalmic)|
|Veterinary use||Carprofen • Deracoxib • Firocoxib • Mavacoxib • Robenacoxib|