Prazepam

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Contents

[edit] BRAND NAMES

  • Demetrin: Austria, Germany, Portugal Serbia, South Africa, Switzerland, South Africa
  • Lysanxia: Belgium, Congo, France, Tunisia
  • Prazene: Italy

[edit] STRUCTURE

File:Prazepam.jpg

[edit] MECHANISM OF ACTION

Prazepam, like other Benzodiazepines bind to specific sites on the gamma-aminobutyric acid-A (GABAA) receptors. This enhances the effects of GABA by increasing its affinity for the GABAA receptor.

Activation of the GABAA receptor, which is linked to a chloride channel (Cl-), results in an influx of Cl- into the neurone causing hyperpolarisation, which results in inhibitory effects on the central nervous system.

Benzodiazepines action on GABAA receptors appears to produce their anxiolytic, sedative, muscle relaxant, hypnotic and anticonvulsant actions.

[edit] INDICATIONS

  • Prazepam is used to treat anxiety and nervous tension requiring sedative treatment.

[edit] DOSAGE

The recommended dose for most adults is 30 mg/day divided in three doses of 10 mg.

In elderly or severely weakened patients, it is recommended that therapy be initiated with 10-15 mg divided throughout the day, to be increased later on, if necessary.

[edit] CONTRAINDICATIONS

  • Hypersensitivity to Prazepam or to any other benzodiazepine
  • Pregnancy
  • Glaucoma (an eye disorder, characterised by increased pressure within the eye)
  • Myasthenia gravis (muscle weakness)
  • Patients with severe breathing difficulties
  • Patients with sleep apnoea syndrome
  • Patients with severe hepatic insufficiency

[edit] PRECAUTIONS

  • Do not drive or do other dangerous activities after taking Prazepam until you feel fully awake.
  • Do not drink alcohol
  • Benzodiazepines can lead to dependency. The risk of dependency increases with the dose and duration of treatment and in patients with a history of alcoholism or dependency on other substances

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

Do not take during pregnancy and if you are breast-feeding

[edit] SIDE EFFECTS

Common side effects include: drowsiness, headache, dizziness, lightheadedness, uncoordinated movements, headache, trembling, problems of self-expression, heart palpitations and dry mouth.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

http://mri.medagencies.org/download/BE_H_0143_002_FinalPL.pdf

[edit] REFERENCES

Sedatives / Hypnotics / Anxiolytics
Benzodiazepines Benzodiazepines (Anxiolytics)‎ Alprazolam (Xanax)   Bromazepam (Lexotan, Lexotanil)   Chlordiazepoxide (Librium)   Clobazam (Frisium)   Clorazepate (Tranxene)   Clotiazepam (Rizen, Tienor)   Delorazepam (EN)   Diazepam (Valium)   Etizolam (Depas)   Ketazolam   Lorazepam (Ativan, Control, Lorans, Tavor, Temesta)   Lormetazepam (Noctamid)   Nordazepam (Nordaz)   Oxazepam (Serepax)   Prazepam (Demetrin, Lysanxia)
Benzodiazepines (Hypnotics) Brotizolam (Lendormin, Bondormin, Dormex, Sintonal, Noctilan)   Clobazam (Frisium)   Estazolam (Esilgan, ProSom)   Etizolam (Depas, Pasaden, Etilaam, Etizest)   Flunitrazepam (Rohypnol)   Flurazepam (Dalmadorm, Dalmane, Felison, Flunox, Valdorm)   Ketazolam (Anseren, Anxon)   Lorazepam (Ativan, Control, Lorans, Tavor, Temesta)   Lormetazepam (Loramet, Minias, Noctamid, Pronoctan, Evamyl)   Midazolam (Dormicum, Hypnovel)   Nitrazepam (Mogadon, Nitrados, Numbon, Radedorm, Alodorm)   Nordazepam (Madar, Nordaz, Stilny, Tranxilium N)   Temazepam (Normison, Restoril, Tenox, Temaze)   Triazolam (Halcion, Hypam, Rilamir)
Non-Benzodiazepine Hypnotics Eszopiclone (Lunesta)   Zolpidem (Ambien, Stilnox, Hypnogen, Sanval, Stilnoct, Zoldem, Zolsana)   Zopiclone (Imovane, Zimovane)
Melatonin agonists Melatonin (Circadin)   Ramelteon (Rozerem)
Orexin agonists Suvorexant (Belsomra)