Cyproterone

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

File:Cyproterone.jpg

[edit] MECHANISM OF ACTION

Cyproterone acetate is a steroidal competitive antagonists at androgen receptors (antiandrogen); decreases action of endogenous hormones (testosterone) in prostate carcinoma; It also has a progestational activity at peripheral receptors; thus, it inhibits secretion of gonadotropin and production of testosterone.

[edit] INDICATIONS

MEN:

  • Antiandrogens like Cyproterone and Bicalutamide (Casodex) are strongly recommended as adjunctive therapy before starting and during the first weeks of GnRH agonist therapy of advanced Prostate Cancer. During the initial phase of GnRH agonist therapy, an initial rise in levels of luteinizing hormone and testosterone, termed the "flare phenomenon," are followed in 2 weeks by a fall in these levels. In order to prevent the initial and temporary rise in serum testosterone, an antiandrogen like cyproterone is used.
  • Cyproterone reduces the force of the sexual urge in men with sexual deviations.
  • Treatment of hot flushes in patients who have had orchidectomy (removal of the testes)


WOMEN:

  • Moderately severe to severe signs of androgenisation
    • moderately severe/severe forms of hirsutism
    • moderately severe/severe androgen-dependent loss of scalp hair (moderately severe/severe androgenic alopaecia)
    • moderately severe/severe forms of acne and/or seborrhoea associated with other features of androgenisation

[edit] DOSAGE

[edit] CONTRAINDICATIONS

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

[edit] RELATED LINKS

Hormone Therapy for Prostate Cancer

[edit] BIBLIOGRAPHY

[edit] REFERENCES