Tacalcitol

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[edit] BRAND NAMES

[edit] STRUCTURE

Tacalcitol.jpg

[edit] MECHANISM OF ACTION

Tacalcitol which is a vitamin D derivate, binds to vitamin D3 receptors on keratinocytes. It inhibits hyper-proliferation of keratinocytes and induces their differentiation, which is the basis for efficacy in psoriasis.

[edit] INDICATIONS

Tacalcitol is used externally to treat cases of mild to moderate psoriasis. Tacalcitol is tolerated on the scalp and face, where calcipotriol tends to irritate.

[edit] DOSAGE

Adults and children over 12 years: Apply once daily to the affected areas, preferably at bedtime. the dose of tacalcitol should not exceed 280 micrograms/week

[edit] CONTRAINDICATIONS

Hypersensitivity to any of the constituents. Hypercalcaemia. Other known disorders of calcium metabolism.

[edit] PRECAUTIONS

  • At the doctor’s discretion, in patients at risk of hypercalcemia, or patients taking high Vitamin D preparations (in excess of 500 IU vitamin D) albumin corrected serum calcium levels should be closely monitored. Treatment should be stopped if hypercalcaemia occurs. Serum calcium levels should also be monitored in patients with renal impairment.
  • When applying to the face avoid contact with the eyes.

[edit] INTERACTIONS

  • No interactions are likely in patients using multivitamin preparations with up to 500 IU vitamin D.
  • UVB radiation can be combined with Tacalcitol. UV radiation should be given in the morning and Tacalcitol lotion/ointment at bedtime.

[edit] PREGNANCY AND LACTATION

  • Animal studies do not indicate direct or indirect harmful affects with respect to pregnancy, embryonal / foetal development, parturition or postnatal development. Caution should be exercised when prescribing to pregnant women.
  • It is not known whether tacalcitol is excreted in human milk. Given the low systemic exposure in humans following topical treatment with tacalcitol, it is probably not necessary to stop breast-feeding during treatment, unless the breast is affected. In that case, either the breast area should not be treated in lactating women who are breast-feeding or breast-feeding should be stopped.

[edit] SIDE EFFECTS

Local skin reactions (itching, erythema, burning) are uncommon. In general, these local reactions are mild and transient.

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