Clotiazepam

BRAND NAMES

• France: Veratran
• Italy: Tienor
• Japan: Isocline, Nilatac, Rilmin, Rize
• Spain: Distensan

STRUCTURE

MECHANISM OF ACTION

Clotiazepam, like other Benzodiazepines bind to specific sites on the gamma-aminobutyric acid-A (GABA_A) receptors. This enhances the effects of GABA by increasing its affinity for the GABA_A receptor.

Activation of the GABA_A receptor, which is linked to a chloride channel (Cl-), results in an influx of Cl- into the neurone causing hyperpolarisation, which results in inhibitory effects on the central nervous system.

Benzodiazepines action on GABA_A receptors appears to produce their anxiolytic, sedative, muscle relaxant, hypnotic and anticonvulsant actions.

REFERENCES

Sedatives / Hypnotics / Anxiolytics
Benzodiazepines	Benzodiazepines (Anxiolytics)‎	Alprazolam (Xanax)  • Bromazepam (Lexotan, Lexotanil)  • Chlordiazepoxide (Librium)  • Clobazam (Frisium)  • Clorazepate (Tranxene)  • Clotiazepam (Rizen, Tienor)  • Delorazepam (EN)  • Diazepam (Valium)  • Etizolam (Depas)  • Ketazolam  • Lorazepam (Ativan, Control, Lorans, Tavor, Temesta)  • Lormetazepam (Noctamid)  • Nordazepam (Nordaz)  • Oxazepam (Serepax)  • Prazepam (Demetrin, Lysanxia)
	Benzodiazepines (Hypnotics)	Brotizolam (Lendormin, Bondormin, Dormex, Sintonal, Noctilan)  • Clobazam (Frisium)  • Estazolam (Esilgan, ProSom)  • Etizolam (Depas, Pasaden, Etilaam, Etizest)  • Flunitrazepam (Rohypnol)  • Flurazepam (Dalmadorm, Dalmane, Felison, Flunox, Valdorm)  • Ketazolam (Anseren, Anxon)  • Lorazepam (Ativan, Control, Lorans, Tavor, Temesta)  • Lormetazepam (Loramet, Minias, Noctamid, Pronoctan, Evamyl)  • Midazolam (Dormicum, Hypnovel)  • Nitrazepam (Mogadon, Nitrados, Numbon, Radedorm, Alodorm)  • Nordazepam (Madar, Nordaz, Stilny, Tranxilium N)  • Temazepam (Normison, Restoril, Tenox, Temaze)  • Triazolam (Halcion, Hypam, Rilamir)
Non-Benzodiazepine Hypnotics	Eszopiclone (Lunesta)  • Zolpidem (Ambien, Stilnox, Hypnogen, Sanval, Stilnoct, Zoldem, Zolsana)  • Zopiclone (Imovane, Zimovane)
Melatonin agonists	Melatonin (Circadin)  • Ramelteon (Rozerem)
Orexin agonists	Suvorexant (Belsomra)