Cloperastine

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[edit] BRAND NAMES

[edit] STRUCTURE

Cloperastine.jpg

[edit] MECHANISM OF ACTION

Cough is a reflex phenomenon occurring when sensitive receptors located in the larynx and upper airways are activated.

Cloperastine is an non-opioid cough suppressant. Levocloperastine acts as:

  • a selective inhibitor on the cough bulbar center.
  • a mild bronchorelaxant and antihistaminic, without acting on the central nervous system or the respiratory center [1]

Unlike Codeine, Cloperastine does not cause addiction or dependence phenomena, sedation and nausea.

[edit] INDICATIONS

Cough suppressant

[edit] DOSAGE

The duration of action of a single dose is 3–4 hours.

  • Adults: 20 mg three times daily for adults.
  • Children:
    • From 2 to 4 years: 8 mg twice daily.
    • From 4 to 7 years: 12 mg twice daily.
    • From 7 to 15 years: 20 mg twice daily

[edit] CONTRAINDICATIONS

  • Children under 2 years of age.
  • Pregnancy and Lactation.
  • Hypersensitivity to any of the product components.

[edit] INTERACTIONS

In both adults and children, the concomitant use of Cloperastine with: alcohol, antihistamines, anticholinergics, sedatives is not recommended.

[edit] PREGNANCY AND LACTATION

Generally contraindicated in pregnancy and during lactation

[edit] SIDE EFFECTS

Uncommon: Drowsiness and dry mouth

[edit] RELATED LINKS

Pharmacological and clinical overview of cloperastine in treatment of cough

[edit] BIBLIOGRAPHY

[edit] REFERENCES

  1. http://www.ncbi.nlm.nih.gov/pubmed/21445282
Antitussives / Cough
Cough suppressants Benzonatate   Butamirate   Codeine   Dextromethorphan   Dihydrocodeine   Dropropizine   Levocloperastine   Levodropropizine   Nepinalone   Oxolamine
Mucolytics Acetylcysteine   Ambroxol (Oral)   Bromhexine   Carbocisteine   Erdosteine   Guaifenesin   Neltenexine