BRAND NAMES
 MECHANISM OF ACTION
Sodium picosulfate is a contact laxative. It increases muscle contractions and speeds up transit of intestinal contents.
Sodium picosulfate is used for short-term treatment of occasional constipation, and to clean the colon before a colonoscopy.
7,5mg/ml drops: (drops should preferably be taken in the evening in order to bring about evacuation on the following morning)
- In adults, the recommendation is to start with 7-8 drops diluted in water, and to decrease the dose if the effect is too great, or to increase it if no laxative effect is achieved.
- In cases of obstinate contipation, up to 15-20 drops diluted in water may be given.
- In children (over 3 years of age): 2-3 drops diluted in water.
2,5mg soft capsules: (capsules should preferably be taken in the evening in order to bring about evacuation on the following morning)
- Children aged 4 to 10 years of age: 1 capsule dialy
- Adult and children over 10 years of age: 2-3 capsules daily.
Like other laxatives, Sodium picosulfate must not be taken every day for long periods of time. If a laxative needs to be used every day, the cause of constipation should be identified.
Hypersensitivity to Sodium picosulfate.
Acute abdominal pain or abdominal pain of unknown origin, nausea or vomiting, intestinal or biliary tract obstruction or stricture, paralytic ileus, acute inflamation of the gastrointestinal tract, rectal bleeding of unknown origin, severe dehydration, gallstones, liver failure.
Caution should be exercised in patients with history of intestinal obstruction, bowel inflammation, severe abdomen pain, dehydration, who are taking other medications, any allergy, during pregnancy and breastfeeding.
Laxatives can reduce the dwelling time in the intestine, and therefore the absorption of other drugs which are given orally at the same time. Therefore, avoid swallowing laxatives and other drugs at the same time: after taking a medicinal product let a space of at least 3 hours elapse before taking a laxative.
Milk or antacids can modify the effect of the medicinal product; let a space of at least 1 hour elapse before taking a laxative.
 PREGNANCY AND LACTATION
There are no adequate and well-controlled studies on the use of sodium picosulfate during pregnancy or lactation. Therefore, although no toxic effects have ever been reported during pregnancy, the medicinal must be used only if the need arises, under direct medical supervision, after assessing the expected benefit for the mother versus the possible risk for the unborn baby.
Although performed studies suggest that sodium picosulfate does not pass into breast milk, this drug must be used only if the need arises, under direct medical supervision, after assessing the expected benefit for the mother versus the possible risk for the unborn baby.
 SIDE EFFECTS
The most common side effects are abdominal cramps and diarrhea.
The use of sodium picosulfate has also been associated with certain electrolyte disturbances, such as hyponatremia and hypokalemia. 
 RELATED LINKS
|Drugs for constipation (laxatives and Prokinetic agents)|
|Softeners, emollients||Liquid paraffin|
|Contact laxatives||Bisacodyl (Dulcolax) • Senna • Cascara • Sodium picosulfate|
|Osmotically acting laxatives||Glycerin suppositories • Magnesium salts • Lactulose (Duphalac) • Macrogol • Mannitol • Sorbitol • Sodium phosphate|
|Prokinetic agents||Clebopride • Prucalopride (Resolor)|
|Others (irritable bowel syndrome accompanied by constipation)||Linaclotide (Constella, Linzess)|