Ciclopirox

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Contents

[edit] BRAND NAMES

  • Batrafen nail lacquer, topical cream (Italy)
  • Loprox
  • Niogermox nail lacquer (Italy)
  • Penlac nail lacquer
  • Sebiprox Shampoo 1,5% (Italy)

[edit] STRUCTURE

Ciclopirox.jpg

[edit] MECHANISM OF ACTION

Ciclopirox is a broad spectrum antifungal. It acts by chelation of polyvalent cations (Fe+3 or Al+3) resulting in the inhibition of the metal-dependent enzymes that are responsible for the degradation of peroxides (toxic metabolites) within the fungal cell.

[edit] INDICATIONS

  • Topical antifungal against cutaneous candidiasis & tinea infections
  • Treatment of mild to moderate onychomycosis

[edit] DOSAGE

Nail lacquer: Should be applied once daily to the affected nail, 5 millimeters of the surrounding skin, and if possible to the nail bed and undersurface of the nail plate. each new application should be placed over the old one, and all coats removed with alcohol each week. initial improvement may take as long as six months.

[edit] CONTRAINDICATIONS

[edit] PRECAUTIONS

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

Nail lacquer: most common adverse events were periungual erythema and erythema of the proximal nail fold. Other adverse events thought to be causally related included nail disorders such as shape change, irritation, ingrown toenail, and discoloration.[1]

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

  1. http://products.sanofi.us/penlac/Penlac.pdf
Antifungals
Ergosterol target : Cell membrane target Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors Imidazoles Topical: Bifonazole   Clotrimazole   Econazole   Fenticonazole   Ketoconazole   Isoconazole   Miconazole   Sertaconazole   Tioconazole
Triazoles Topical: Fluconazole   Terconazole
Systemic: Fluconazole   Itraconazole   Posaconazole   Voriconazole
Polyene antimycotics (ergosterol binding; they form pores in the membrane) Topical: Nystatin
Systemic: Amphotericin B
Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors Topical: Amorolfine   Naftifine   Terbinafine
Systemic: Terbinafine
Echinocandins (β-glucan synthase inhibitors) : Cell wall target Anidulafungin   Caspofungin   Micafungin
Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors Flucytosine
Mitotic inhibitors Griseofulvin
Others Ciclopirox