Cetirizine

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Cetirizine.jpg

[edit] MECHANISM OF ACTION

Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The low incidence of sedation can be attributed to reduced penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side chain.

[edit] INDICATIONS

  • Urticaria
  • Seasonal and perennial allergic rhinitis to relief symptoms such as sneezing, rhinorrhea and nasal pruritus, occular pruritus and tearing.
  • Allergic asthma
  • Atopic dermatitis

[edit] DOSAGE

  • Adults and children 12 years and older: 10 mg/day
  • Children 6 to 11 Years: 5-10 mg once daily depending on symptom severity
  • Children 2 to 5 Years: The recommended initial dose is 2.5 mg once daily. Max: 5 mg/day
  • Children 6 months to <2 years: 2.5 mg/day. Max: 2.5 mg every 12 hours

[edit] CONTRAINDICATIONS

[edit] WARNINGS AND PRECAUTIONS

  • Somnolence has been reported in patients taking Cetirizine. Caution should be exercised when driving a car or operating potentially dangerous machinery.
  • Epilepsy: CNS stimulation may occur with antihistamines, especially in children. Therefore caution is recommended when treating patients suffering from epilepsy.

[edit] INTERACTIONS

  • Cetirizine may enhance the sedative effect of central nervous system depressants including alcohol, barbiturates, hypnotics, narcotic analgesics, tricyclic antidepressants, sedatives and tranquillisers.

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category B (US). Cetirizine should be used during pregnancy only if clearly needed.
  • Nursing mothers: Cetirizine has been reported to be excreted in human breast milk. Using Cetirizine by nursing mothers is not recommended.

[edit] SIDE EFFECTS

Most common: Somnolence, fatigue and dry mouth

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES