BRAND NAMES
- International: Cancidas
 MECHANISM OF ACTION
Caspofungin is a compound of natural origin, possibly from actinomycetes comes its echinocardin precursor.
Caspofungin itself is a semi-synthetic derivative. Caspofungin inhibits the synthesis of β-1-3-D-glucans present outside the plasma membrane. This leads to cell wall weakening that favours the cell wall lysis and death of the fungi.
Caspofungin is mainly active against Candida, Aspergillus and Pneumocystis. It can only be given by the IV route and it does not cross the BBB.
Caspofungin is used in case of aspergillosis and candidiasis in patients that don’t respond to other agents.
Caspofungin has a very low extent of interaction with CYP450, thus having a low potential of drug interaction, not comparable at all withthe azoles.
 PREGNANCY AND LACTATION
Caspofungin cannot be given to pregnant women because of its embryotoxicity.
 SIDE EFFECTS
 RELATED LINKS
|Ergosterol target : Cell membrane target||Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors||Imidazoles||Topical: Bifonazole • Clotrimazole • Econazole • Fenticonazole • Ketoconazole • Isoconazole • Miconazole • Sertaconazole • Tioconazole|
|Triazoles|| Topical: Fluconazole • Terconazole|
Systemic: Fluconazole • Itraconazole • Posaconazole • Voriconazole
|Polyene antimycotics (ergosterol binding; they form pores in the membrane)|| Topical: Nystatin |
Systemic: Amphotericin B
|Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors|| Topical: Amorolfine • Naftifine • Terbinafine |
|Echinocandins (β-glucan synthase inhibitors) : Cell wall target||Anidulafungin • Caspofungin • Micafungin|
|Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors||Flucytosine|