Caspofungin

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Caspofungin.jpg

[edit] MECHANISM OF ACTION

Caspofungin is a compound of natural origin, possibly from actinomycetes comes its echinocardin precursor.

Caspofungin itself is a semi-synthetic derivative. Caspofungin inhibits the synthesis of β-1-3-D-glucans present outside the plasma membrane. This leads to cell wall weakening that favours the cell wall lysis and death of the fungi.

Caspofungin is mainly active against Candida, Aspergillus and Pneumocystis. It can only be given by the IV route and it does not cross the BBB.

[edit] INDICATIONS

Caspofungin is used in case of aspergillosis and candidiasis in patients that don’t respond to other agents.

[edit] DOSAGE

[edit] CONTRAINDICATIONS

[edit] PRECAUTIONS

[edit] INTERACTIONS

Caspofungin has a very low extent of interaction with CYP450, thus having a low potential of drug interaction, not comparable at all withthe azoles.

[edit] PREGNANCY AND LACTATION

Caspofungin cannot be given to pregnant women because of its embryotoxicity.

[edit] SIDE EFFECTS

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Antifungals
Ergosterol target : Cell membrane target Azoles (lanosterol 14 alpha-demethylase inhibitors) : Ergosterol inhibitors Imidazoles Topical: Bifonazole   Clotrimazole   Econazole   Fenticonazole   Ketoconazole   Isoconazole   Miconazole   Sertaconazole   Tioconazole
Triazoles Topical: Fluconazole   Terconazole
Systemic: Fluconazole   Itraconazole   Posaconazole   Voriconazole
Polyene antimycotics (ergosterol binding; they form pores in the membrane) Topical: Nystatin
Systemic: Amphotericin B
Allylamines (squalene epoxidase inhibitors) : Ergosterol inhibitors Topical: Amorolfine   Naftifine   Terbinafine
Systemic: Terbinafine
Echinocandins (β-glucan synthase inhibitors) : Cell wall target Anidulafungin   Caspofungin   Micafungin
Pyrimidine analogues / Thymidylate synthase inhibitors : Nucleic acid inhibitors Flucytosine
Mitotic inhibitors Griseofulvin
Others Ciclopirox